人 FTCD 抗体对
01AB00325
FTCD (Formimidoyltransferase Cyclodeaminase) is an enzyme involved in the metabolism of histidine and folate production. It plays a crucial role as a tumor suppressor in hepatocellular carcinoma (HCC). Downregulation of FTCD expression, often caused by DNA methylation, is strongly associated with HCC progression, larger tumor size, vascular invasion, advanced tumor stage, and poor survival. FTCD deletion promotes lipid accumulation and malignant transformation in HCC mouse models. Clinically, lower FTCD levels correlate with higher HCC risk in cirrhotic patients. Mutations in FTCD can also cause glutamate formiminotransferase deficiency, a rare disorder affecting physical and mental development, with a severe form characterized by profound intellectual disability and megaloblastic anemia.
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技术参数
- 靶点基因名
- FTCD
- 蛋白别名
- formimidoyltransferase cyclodeaminase; FTCD
- UniProt
- O95954
- 物种
- Human
产品详情
- 靶点名称
- FTCD
- 蛋白名称
- formimidoyltransferase cyclodeaminase
- 蛋白别名
- Formimidoyltransferase-cyclodeaminase; Formiminotransferase-cyclodeaminase; FTCD; LCHC1) [Includes: Glutamate formimidoyltransferase; Glutamate formiminotransferase; Glutamate formyltransferase; Formimidoyltetrahydrofolate cyclodeaminase; Formiminotetrahydrofolate cyclodeaminase]
- 靶点基因名
- FTCD
- UniProt
- O95954
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
FTCD (Formimidoyltransferase Cyclodeaminase) is an enzyme involved in the metabolism of histidine and folate production. It plays a crucial role as a tumor suppressor in hepatocellular carcinoma (HCC). Downregulation of FTCD expression, often caused by DNA methylation, is strongly associated with HCC progression, larger tumor size, vascular invasion, advanced tumor stage, and poor survival. FTCD deletion promotes lipid accumulation and malignant transformation in HCC mouse models. Clinically, lower FTCD levels correlate with higher HCC risk in cirrhotic patients. Mutations in FTCD can also cause glutamate formiminotransferase deficiency, a rare disorder affecting physical and mental development, with a severe form characterized by profound intellectual disability and megaloblastic anemia.