人 FST 抗体对
01AB04032
Follistatin (FST) is a glycoprotein primarily known for its role in muscle growth and repair through the inhibition of members of the transforming growth factor-beta (TGF-β) superfamily, particularly activins and myostatin. It is secreted by various tissues, with the highest concentrations found in the ovaries and skin, where it aids in cellular differentiation and tissue regeneration. Follistatin exists in multiple isoforms, including FST315 and FST288, which differ in their binding affinities due to variations in their heparin-binding sites (HBS) that influence their interactions with extracellular matrix components. Elevated follistatin levels have been linked to several diseases, including type 2 diabetes, heart failure, and chronic kidney disease, as it may contribute to insulin resistance and inflammation. Additionally, follistatin has therapeutic potential for neuromuscular disorders by promoting localized muscle hypertrophy.
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技术参数
- 靶点基因名
- FST
- 蛋白别名
- follistatin; FST
- UniProt
- P19883
- 物种
- Human
产品详情
- 靶点名称
- FST
- 蛋白名称
- follistatin
- 蛋白别名
- Follistatin; FS; Activin-binding protein
- 靶点基因名
- FST
- UniProt
- P19883
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Follistatin (FST) is a glycoprotein primarily known for its role in muscle growth and repair through the inhibition of members of the transforming growth factor-beta (TGF-β) superfamily, particularly activins and myostatin. It is secreted by various tissues, with the highest concentrations found in the ovaries and skin, where it aids in cellular differentiation and tissue regeneration. Follistatin exists in multiple isoforms, including FST315 and FST288, which differ in their binding affinities due to variations in their heparin-binding sites (HBS) that influence their interactions with extracellular matrix components. Elevated follistatin levels have been linked to several diseases, including type 2 diabetes, heart failure, and chronic kidney disease, as it may contribute to insulin resistance and inflammation. Additionally, follistatin has therapeutic potential for neuromuscular disorders by promoting localized muscle hypertrophy.