人 FRZB 抗体对
01AB00500
Frizzled related protein (FRZB), also known as secreted frizzled related protein 3 (SFRP3), is a Wnt-binding protein crucial in embryonic development, particularly in skeletal development and bone morphogenesis. It is a competitor for the cell-surface G-protein receptor Frizzled and lacks the 7 transmembrane domains found in G-protein-coupled receptors but contains a conserved cysteine-rich domain (CRD) and an intracellular C-terminus essential for signaling. FRZB is expressed in chondrocytes and plays a significant role in the development and maintenance of bone, cartilage, and joints by inhibiting the Wnt/β-catenin pathway. Defects in FRZB are associated with an increased susceptibility to osteoarthritis, particularly female-specific osteoarthritis. Additionally, FRZB has been implicated in metabolic diseases such as lipid metabolism, obesity, type 2 diabetes mellitus, and cardiovascular diseases.
| 规格 | 起售价 |
|---|---|
| 登录后可查看 | |
技术参数
- 靶点基因名
- FRZB
- 基因别名
- FIZ; FRE; FRP; FRZB1; SFRP3
- 蛋白别名
- frizzled related protein; FRZB
- UniProt
- Q92765
- 物种
- Human
产品详情
- 靶点名称
- FRZB
- 蛋白名称
- frizzled related protein
- 蛋白别名
- Secreted frizzled-related protein 3; sFRP-3; Frezzled; Fritz; Frizzled-related protein 1; FrzB-1
- 靶点基因名
- FRZB
- 基因别名
- FIZ; FRE; FRP; FRZB1; SFRP3
- UniProt
- Q92765
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Frizzled related protein (FRZB), also known as secreted frizzled related protein 3 (SFRP3), is a Wnt-binding protein crucial in embryonic development, particularly in skeletal development and bone morphogenesis. It is a competitor for the cell-surface G-protein receptor Frizzled and lacks the 7 transmembrane domains found in G-protein-coupled receptors but contains a conserved cysteine-rich domain (CRD) and an intracellular C-terminus essential for signaling. FRZB is expressed in chondrocytes and plays a significant role in the development and maintenance of bone, cartilage, and joints by inhibiting the Wnt/β-catenin pathway. Defects in FRZB are associated with an increased susceptibility to osteoarthritis, particularly female-specific osteoarthritis. Additionally, FRZB has been implicated in metabolic diseases such as lipid metabolism, obesity, type 2 diabetes mellitus, and cardiovascular diseases.