人 FRS2 抗体对
01AB00498
Fibroblast growth factor receptor substrate 2 (FRS2) is an 80 kDa membrane-anchored signal transducing adaptor protein that plays a crucial role in linking activated receptor tyrosine kinases (RTKs) to various downstream signaling pathways, including the MAPK/ERK and PI3K/AKT/mTOR pathways. This protein is encoded by the FRS2 gene in humans and is essential for mediating cellular responses to fibroblast growth factors (FGFs) and nerve growth factor (NGF) receptors. Its properties include the ability to interact with multiple signaling molecules, thereby modulating critical cellular functions like proliferation and differentiation. Dysregulation of FRS2 has been implicated in various diseases, including pigmentation disorders and certain types of cancer, such as prostate cancer.
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技术参数
- 靶点基因名
- FRS2
- 蛋白别名
- fibroblast growth factor receptor substrate 2; FRS2
- UniProt
- Q8WU20
- 物种
- Human
产品详情
- 靶点名称
- FRS2
- 蛋白名称
- fibroblast growth factor receptor substrate 2
- 蛋白别名
- Fibroblast growth factor receptor substrate 2; FGFR substrate 2; FGFR-signaling adaptor SNT; Suc1-associated neurotrophic factor target 1; SNT-1
- 靶点基因名
- FRS2
- UniProt
- Q8WU20
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Fibroblast growth factor receptor substrate 2 (FRS2) is an 80 kDa membrane-anchored signal transducing adaptor protein that plays a crucial role in linking activated receptor tyrosine kinases (RTKs) to various downstream signaling pathways, including the MAPK/ERK and PI3K/AKT/mTOR pathways. This protein is encoded by the FRS2 gene in humans and is essential for mediating cellular responses to fibroblast growth factors (FGFs) and nerve growth factor (NGF) receptors. Its properties include the ability to interact with multiple signaling molecules, thereby modulating critical cellular functions like proliferation and differentiation. Dysregulation of FRS2 has been implicated in various diseases, including pigmentation disorders and certain types of cancer, such as prostate cancer.