人 FOXP3 抗体对
01AB03109
Forkhead box protein P3 (FOXP3) is a master regulator of regulatory T cell (Treg) development and function, playing a crucial role in maintaining immune homeostasis and self-tolerance. It contains several functional domains, including a proline-rich N-terminal domain, a zinc-finger and leucine-zipper domain, and a C-terminal forkhead domain responsible for DNA binding. FOXP3 acts as both a transcriptional activator and repressor, interacting with various proteins to modulate gene expression in Tregs. It is essential for the stability and suppressive function of Tregs, which suppress excessive immune responses and prevent autoimmunity. Mutations or dysregulation of FOXP3 can lead to severe autoimmune diseases like IPEX syndrome, characterized by multi-organ inflammation and autoantibody production. Additionally, altered FOXP3 expression has been linked to cancer, where it may influence tumor immunity and progression.
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技术参数
- 靶点基因名
- FOXP3
- 基因别名
- IPEX
- 蛋白别名
- forkhead box P3; FOXP3
- UniProt
- Q9BZS1
- 物种
- Human
产品详情
- 靶点名称
- FOXP3
- 蛋白名称
- forkhead box P3
- 蛋白别名
- Forkhead box protein P3; Scurfin) [Cleaved into: Forkhead box protein P3; C-terminally processed; Forkhead box protein P3 41 kDa form]
- 靶点基因名
- FOXP3
- 基因别名
- IPEX
- UniProt
- Q9BZS1
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Forkhead box protein P3 (FOXP3) is a master regulator of regulatory T cell (Treg) development and function, playing a crucial role in maintaining immune homeostasis and self-tolerance. It contains several functional domains, including a proline-rich N-terminal domain, a zinc-finger and leucine-zipper domain, and a C-terminal forkhead domain responsible for DNA binding. FOXP3 acts as both a transcriptional activator and repressor, interacting with various proteins to modulate gene expression in Tregs. It is essential for the stability and suppressive function of Tregs, which suppress excessive immune responses and prevent autoimmunity. Mutations or dysregulation of FOXP3 can lead to severe autoimmune diseases like IPEX syndrome, characterized by multi-organ inflammation and autoantibody production. Additionally, altered FOXP3 expression has been linked to cancer, where it may influence tumor immunity and progression.