人 FOXJ3 抗体对
01AB04028
Forkhead box protein J3 (FOXJ3) is a member of the forkhead transcription factor family, characterized by its winged-helix DNA-binding domain, which enables it to regulate gene expression involved in various biological processes. FOXJ3 is primarily expressed in skeletal muscle and plays a critical role in myogenesis, particularly in determining muscle fiber type identity and promoting muscle regeneration. It functions by transcriptionally activating genes such as Mef2c, which is essential for muscle differentiation and function. Dysregulation of FOXJ3 has been implicated in several diseases, particularly muscular dystrophies, where impaired muscle regeneration leads to progressive weakness and degeneration of muscle tissue. Additionally, FOXJ3 has been associated with metabolic disorders due to its role in mitochondrial biogenesis and energy metabolism.
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技术参数
- 靶点基因名
- FOXJ3
- 基因别名
- KIAA1041
- 蛋白别名
- forkhead box J3; FOXJ3
- UniProt
- Q9UPW0
- 物种
- Human
产品详情
- 靶点名称
- FOXJ3
- 蛋白名称
- forkhead box J3
- 蛋白别名
- Forkhead box protein J3
- 靶点基因名
- FOXJ3
- 基因别名
- KIAA1041
- UniProt
- Q9UPW0
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Forkhead box protein J3 (FOXJ3) is a member of the forkhead transcription factor family, characterized by its winged-helix DNA-binding domain, which enables it to regulate gene expression involved in various biological processes. FOXJ3 is primarily expressed in skeletal muscle and plays a critical role in myogenesis, particularly in determining muscle fiber type identity and promoting muscle regeneration. It functions by transcriptionally activating genes such as Mef2c, which is essential for muscle differentiation and function. Dysregulation of FOXJ3 has been implicated in several diseases, particularly muscular dystrophies, where impaired muscle regeneration leads to progressive weakness and degeneration of muscle tissue. Additionally, FOXJ3 has been associated with metabolic disorders due to its role in mitochondrial biogenesis and energy metabolism.