人 FOLR3 抗体对
01AB01695
Folate receptor gamma (FOLR3) is a secreted glycoprotein member of the high-affinity folate receptor family. Unlike other family members that are membrane-anchored, FOLR3 lacks a functional glycosylphosphatidylinositol attachment signal and is constitutively released from hematopoietic tissues such as the bone marrow and spleen. It binds folic acid and reduced folate derivatives with high affinity, mediating the cellular delivery of 5-methyltetrahydrofolate. Clinically, FOLR3 is utilized as a biomarker in hematopoietic malignancies and lung cancer, where its expression and methylation status are often altered. Additionally, secreted FOLR3 has been implicated in the pathogenesis of metabolic dysfunction-associated steatohepatitis (MASH), where it acts to amplify TGF-beta signaling in hepatic stellate cells, thereby driving the progression of liver fibrosis.
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技术参数
- 靶点基因名
- FOLR3
- 蛋白别名
- folate receptor gamma; FOLR3
- UniProt
- P41439
- 物种
- Human
产品详情
- 靶点名称
- FOLR3
- 蛋白名称
- folate receptor gamma
- 蛋白别名
- Folate receptor gamma; FR-gamma; Folate receptor 3
- 靶点基因名
- FOLR3
- UniProt
- P41439
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Folate receptor gamma (FOLR3) is a secreted glycoprotein member of the high-affinity folate receptor family. Unlike other family members that are membrane-anchored, FOLR3 lacks a functional glycosylphosphatidylinositol attachment signal and is constitutively released from hematopoietic tissues such as the bone marrow and spleen. It binds folic acid and reduced folate derivatives with high affinity, mediating the cellular delivery of 5-methyltetrahydrofolate. Clinically, FOLR3 is utilized as a biomarker in hematopoietic malignancies and lung cancer, where its expression and methylation status are often altered. Additionally, secreted FOLR3 has been implicated in the pathogenesis of metabolic dysfunction-associated steatohepatitis (MASH), where it acts to amplify TGF-beta signaling in hepatic stellate cells, thereby driving the progression of liver fibrosis.