人 FMN1 抗体对
01AB00819
Formin 1 (FMN1), is a multidomain protein that plays a crucial role in the regulation of the actin and microtubule cytoskeleton, impacting essential cellular processes such as cell polarity, migration, and cytokinesis. FMN1 contains several conserved domains, including the formin homology domains FH1 and FH2, which are central to its ability to promote actin filament polymerization and interact with actin-binding proteins like profilin. The FH2 domain enables FMN1 to nucleate actin filaments and associate with the barbed end, while additional domains facilitate interactions with signaling molecules and proper subcellular localization. FMN1 is also involved in the formation of adherens junctions and the assembly of linear actin cables, contributing to cell-cell adhesion and tissue integrity. Mutations in FMN1 have been linked to limb deformities in animal models, highlighting its importance in developmental processes and suggesting a role in congenital limb malformations in humans.
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技术参数
- 靶点基因名
- FMN1
- 基因别名
- FMN; LD
- 蛋白别名
- formin 1; FMN1
- UniProt
- Q68DA7
- 物种
- Human
产品详情
- 靶点名称
- FMN1
- 蛋白名称
- formin 1
- 蛋白别名
- Formin-1; Limb deformity protein homolog
- 靶点基因名
- FMN1
- 基因别名
- FMN; LD
- UniProt
- Q68DA7
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Formin 1 (FMN1), is a multidomain protein that plays a crucial role in the regulation of the actin and microtubule cytoskeleton, impacting essential cellular processes such as cell polarity, migration, and cytokinesis. FMN1 contains several conserved domains, including the formin homology domains FH1 and FH2, which are central to its ability to promote actin filament polymerization and interact with actin-binding proteins like profilin. The FH2 domain enables FMN1 to nucleate actin filaments and associate with the barbed end, while additional domains facilitate interactions with signaling molecules and proper subcellular localization. FMN1 is also involved in the formation of adherens junctions and the assembly of linear actin cables, contributing to cell-cell adhesion and tissue integrity. Mutations in FMN1 have been linked to limb deformities in animal models, highlighting its importance in developmental processes and suggesting a role in congenital limb malformations in humans.