人 FLII 抗体对
01AB03304
FLII actin remodeling protein (FLII) is a multifunctional actin-remodeling protein of the gelsolin family, featuring an N-terminal leucine-rich repeat (LRR) domain and C-terminal gelsolin-like domains. It functions as an actin-capping and polymerization-inhibiting factor, regulating filament length and focal adhesion dynamics without severing actin. Beyond the cytoskeleton, FLII acts as a transcriptional coactivator and signaling scaffold, integrating cytoskeletal remodeling with nuclear receptor signaling. FLII is recognized as a negative regulator of wound repair; its elevated expression impairs re-epithelialization and collagen remodeling, while its inhibition improves healing outcomes, making it a potential therapeutic target for chronic wounds and fibrosis.
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技术参数
- 靶点基因名
- FLII
- 基因别名
- FLIL
- 蛋白别名
- FLII actin remodeling protein; FLII
- UniProt
- Q13045
- 物种
- Human
产品详情
- 靶点名称
- FLII
- 蛋白名称
- FLII actin remodeling protein
- 蛋白别名
- Protein flightless-1 homolog
- 靶点基因名
- FLII
- 基因别名
- FLIL
- UniProt
- Q13045
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
FLII actin remodeling protein (FLII) is a multifunctional actin-remodeling protein of the gelsolin family, featuring an N-terminal leucine-rich repeat (LRR) domain and C-terminal gelsolin-like domains. It functions as an actin-capping and polymerization-inhibiting factor, regulating filament length and focal adhesion dynamics without severing actin. Beyond the cytoskeleton, FLII acts as a transcriptional coactivator and signaling scaffold, integrating cytoskeletal remodeling with nuclear receptor signaling. FLII is recognized as a negative regulator of wound repair; its elevated expression impairs re-epithelialization and collagen remodeling, while its inhibition improves healing outcomes, making it a potential therapeutic target for chronic wounds and fibrosis.