抗人 FKBP5 抗体对
01AB00673
FKBP prolyl isomerase 5 (FKBP5) is a protein that belongs to the immunophilin family and plays a crucial role in immunoregulation and basic cellular processes involving protein folding and trafficking. It is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin, mediating calcineurin inhibition. FKBP5 interacts functionally with mature corticoid receptor hetero-complexes and the 90 kDa heat shock protein, influencing steroid hormone receptor responsiveness and stress endocrinology. FKBP5 has been associated with a higher rate of depressive disorders and neurodegenerative diseases, with decreased methylation in the promoter region observed in patients with these conditions. The protein is also an attractive drug target for stress-related disorders, chronic pain, and obesity, with selective inhibitors like SAFit2 showing promising effects in animal models.
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技术参数
- 靶点基因名
- FKBP5
- 基因别名
- AIG6; FKBP51
- 蛋白别名
- FKBP prolyl isomerase 5; FKBP5
- UniProt
- Q13451
- 物种
- Human
产品详情
- 靶点名称
- FKBP5
- 蛋白名称
- FKBP prolyl isomerase 5
- 蛋白别名
- Peptidyl-prolyl cis-trans isomerase FKBP5; PPIase FKBP5; 51 kDa FK506-binding protein; 51 kDa FKBP; FKBP-51; 54 kDa progesterone receptor-associated immunophilin; Androgen-regulated protein 6; FF1 antigen; FK506-binding protein 5; FKBP-5; FKBP54; p54; HSP90-binding immunophilin; Rotamase
- 靶点基因名
- FKBP5
- 基因别名
- AIG6; FKBP51
- UniProt
- Q13451
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
FKBP prolyl isomerase 5 (FKBP5) is a protein that belongs to the immunophilin family and plays a crucial role in immunoregulation and basic cellular processes involving protein folding and trafficking. It is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin, mediating calcineurin inhibition. FKBP5 interacts functionally with mature corticoid receptor hetero-complexes and the 90 kDa heat shock protein, influencing steroid hormone receptor responsiveness and stress endocrinology. FKBP5 has been associated with a higher rate of depressive disorders and neurodegenerative diseases, with decreased methylation in the promoter region observed in patients with these conditions. The protein is also an attractive drug target for stress-related disorders, chronic pain, and obesity, with selective inhibitors like SAFit2 showing promising effects in animal models.