人 FKBP12 抗体对
01AB03059
FKBP prolyl isomerase 1A (FKBP12), or FKBP1A, is a cytosolic immunophilin with peptidyl-prolyl cis-trans isomerase activity that assists in protein folding. It is best known for binding the immunosuppressants FK506 and rapamycin; these drug-protein complexes inhibit calcineurin and mTOR, respectively. Through these interactions, FKBP12 plays a pivotal role in modulating T-cell activation, adaptive immunity, and cell growth pathways. Additionally, FKBP12 regulates intracellular calcium release channels, including ryanodine receptors, thereby influencing cardiac contractility and neuronal signaling. Perturbation of FKBP12 function is associated with mechanisms underlying cardiomyopathy and neurotoxicity.
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技术参数
- 靶点基因名
- FKBP1A
- 基因别名
- FKBP1; FKBP12
- 蛋白别名
- FKBP prolyl isomerase 1A; FKBP12
- UniProt
- P62942
- 物种
- Human
产品详情
- 靶点名称
- FKBP12
- 蛋白名称
- FKBP prolyl isomerase 1A
- 蛋白别名
- Peptidyl-prolyl cis-trans isomerase FKBP1A; PPIase FKBP1A; 12 kDa FK506-binding protein; 12 kDa FKBP; FKBP-12; Calstabin-1; FK506-binding protein 1A; FKBP-1A; Immunophilin FKBP12; Rotamase
- 靶点基因名
- FKBP1A
- 基因别名
- FKBP1; FKBP12
- UniProt
- P62942
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
FKBP prolyl isomerase 1A (FKBP12), or FKBP1A, is a cytosolic immunophilin with peptidyl-prolyl cis-trans isomerase activity that assists in protein folding. It is best known for binding the immunosuppressants FK506 and rapamycin; these drug-protein complexes inhibit calcineurin and mTOR, respectively. Through these interactions, FKBP12 plays a pivotal role in modulating T-cell activation, adaptive immunity, and cell growth pathways. Additionally, FKBP12 regulates intracellular calcium release channels, including ryanodine receptors, thereby influencing cardiac contractility and neuronal signaling. Perturbation of FKBP12 function is associated with mechanisms underlying cardiomyopathy and neurotoxicity.