人 FGR 抗体对
01AB00814
FGR proto-oncogene, Src family tyrosine kinase (FGR) is a member of the Src family of protein tyrosine kinases. The protein contains N-terminal sites for myristoylation and palmitoylation, a PTK domain, and SH2 and SH3 domains involved in protein-protein interactions. FGR functions as a non-receptor tyrosine kinase that transmits signals from cell surface receptors and regulates immune responses, including neutrophil, monocyte, macrophage, and mast cell functions. It plays a role in cytoskeleton remodeling, phagocytosis, cell adhesion, and migration. FGR is involved in mast cell degranulation and the release of inflammatory cytokines. Diseases associated with FGR include placental insufficiency and endometriosis of pelvic peritoneum. The protein localizes to plasma membrane ruffles and negatively regulates cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway.
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技术参数
- 靶点基因名
- FGR
- 基因别名
- SRC2
- 蛋白别名
- FGR proto-oncogene, Src family tyrosine kinase; FGR
- UniProt
- P09769
- 物种
- Human
产品详情
- 靶点名称
- FGR
- 蛋白名称
- FGR proto-oncogene, Src family tyrosine kinase
- 蛋白别名
- Tyrosine-protein kinase Fgr; Gardner-Rasheed feline sarcoma viral; v-fgr) oncogene homolog; Proto-oncogene c-Fgr; p55-Fgr; p58-Fgr; p58c-Fgr
- 靶点基因名
- FGR
- 基因别名
- SRC2
- UniProt
- P09769
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
FGR proto-oncogene, Src family tyrosine kinase (FGR) is a member of the Src family of protein tyrosine kinases. The protein contains N-terminal sites for myristoylation and palmitoylation, a PTK domain, and SH2 and SH3 domains involved in protein-protein interactions. FGR functions as a non-receptor tyrosine kinase that transmits signals from cell surface receptors and regulates immune responses, including neutrophil, monocyte, macrophage, and mast cell functions. It plays a role in cytoskeleton remodeling, phagocytosis, cell adhesion, and migration. FGR is involved in mast cell degranulation and the release of inflammatory cytokines. Diseases associated with FGR include placental insufficiency and endometriosis of pelvic peritoneum. The protein localizes to plasma membrane ruffles and negatively regulates cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway.