抗人 FGFR2 抗体对
01AB01139
Fibroblast growth factor receptor 2 (FGFR2) is a transmembrane protein that spans the cell membrane with one end inside the cell and the other projecting from the outer surface. It functions as a receptor for fibroblast growth factors, triggering chemical reactions that regulate critical cellular processes including proliferation, differentiation, bone development, angiogenesis, wound healing, and embryonic development. FGFR2 plays a crucial role in bone growth and remodeling, particularly during embryonic development where it signals immature cells to become bone cells and form tissues such as the head, hands, and feet. The protein exists in several isoforms with tissue-specific expression patterns that may change throughout development. Mutations in FGFR2 are associated with various skeletal disorders and conditions affecting bone formation. Recent research indicates that FGFR2 promotes proliferation, migration, and invasion of ectopic stromal cells through activation of extracellular signaling pathways.
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技术参数
- 靶点基因名
- FGFR2
- 基因别名
- BEK; KGFR; KSAM
- 蛋白别名
- fibroblast growth factor receptor 2; FGFR2
- UniProt
- P21802
- 物种
- Human
产品详情
- 靶点名称
- FGFR2
- 蛋白名称
- fibroblast growth factor receptor 2
- 蛋白别名
- Fibroblast growth factor receptor 2; FGFR-2; K-sam; KGFR; Keratinocyte growth factor receptor; CD antigen CD332
- 靶点基因名
- FGFR2
- 基因别名
- BEK; KGFR; KSAM
- UniProt
- P21802
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Fibroblast growth factor receptor 2 (FGFR2) is a transmembrane protein that spans the cell membrane with one end inside the cell and the other projecting from the outer surface. It functions as a receptor for fibroblast growth factors, triggering chemical reactions that regulate critical cellular processes including proliferation, differentiation, bone development, angiogenesis, wound healing, and embryonic development. FGFR2 plays a crucial role in bone growth and remodeling, particularly during embryonic development where it signals immature cells to become bone cells and form tissues such as the head, hands, and feet. The protein exists in several isoforms with tissue-specific expression patterns that may change throughout development. Mutations in FGFR2 are associated with various skeletal disorders and conditions affecting bone formation. Recent research indicates that FGFR2 promotes proliferation, migration, and invasion of ectopic stromal cells through activation of extracellular signaling pathways.