人 FGF5 抗体对
01AB03583
Fibroblast Growth Factor 5 (FGF5) is a protein encoded by the FGF5 gene in humans, consisting of 268 amino acids and weighing approximately 29.1 kDa. It plays a crucial role in various biological processes, particularly in regulating the hair growth cycle by signaling the transition from the anagen (growth) phase to the catagen (regression) phase. The protein interacts with specific tyrosine kinase receptors (FGFR1), and its expression is notably high during the late anagen phase of hair follicles. Mutations in FGF5 have been linked to conditions such as familial trichomegaly, characterized by excessively long eyelashes and hair, and androgenetic alopecia, where polymorphisms in FGF5 are associated with male pattern baldness. Additionally, FGF5 has been implicated in other diseases; for example, it has protective roles against sepsis-induced cardiac injury by modulating cellular pathways.
| 规格 | 起售价 |
|---|---|
| 登录后可查看 | |
技术参数
- 靶点基因名
- FGF5
- 蛋白别名
- fibroblast growth factor 5; FGF5
- UniProt
- P12034
- 物种
- Human
产品详情
- 靶点名称
- FGF5
- 蛋白名称
- fibroblast growth factor 5
- 蛋白别名
- Fibroblast growth factor 5; FGF-5; Heparin-binding growth factor 5; HBGF-5; Smag-82
- 靶点基因名
- FGF5
- UniProt
- P12034
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Fibroblast Growth Factor 5 (FGF5) is a protein encoded by the FGF5 gene in humans, consisting of 268 amino acids and weighing approximately 29.1 kDa. It plays a crucial role in various biological processes, particularly in regulating the hair growth cycle by signaling the transition from the anagen (growth) phase to the catagen (regression) phase. The protein interacts with specific tyrosine kinase receptors (FGFR1), and its expression is notably high during the late anagen phase of hair follicles. Mutations in FGF5 have been linked to conditions such as familial trichomegaly, characterized by excessively long eyelashes and hair, and androgenetic alopecia, where polymorphisms in FGF5 are associated with male pattern baldness. Additionally, FGF5 has been implicated in other diseases; for example, it has protective roles against sepsis-induced cardiac injury by modulating cellular pathways.