人 FGF2 抗体对
01AB00153
FGF2, also known as basic fibroblast growth factor, is a key regulator of cellular function in various tissues. It binds and activates FGF receptors, primarily through the RAS-MAPK pathway, to regulate processes like cell proliferation, migration, differentiation, and angiogenesis. FGF2 has been implicated in a number of diseases and pathological conditions. It plays an important role in wound healing and tissue engineering, but its overexpression can also lead to cellular overgrowth and malignancy. FGF2 has been linked to bone disorders like osteoporosis, osteomalacia, and pathological bone fractures by impacting genetic expression and signaling pathways. It has also been associated with neurological conditions such as Parkinson's disease, Alzheimer's disease, and schizophrenia, where altered FGF2 levels can have both positive and negative effects. Additionally, FGF2 has been shown to function as an immunomodulatory factor, regulating inflammatory processes in diseases like asthma and COPD. Overall, the diverse functions of FGF2 make it an important target for understanding and potentially treating a wide range of diseases.
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技术参数
- 靶点基因名
- FGF2
- 基因别名
- FGFB
- 蛋白别名
- fibroblast growth factor 2; FGF2
- UniProt
- P09038
- 物种
- Human
产品详情
- 靶点名称
- FGF2
- 蛋白名称
- fibroblast growth factor 2
- 蛋白别名
- Fibroblast growth factor 2; FGF-2; Basic fibroblast growth factor; bFGF; Heparin-binding growth factor 2; HBGF-2
- 靶点基因名
- FGF2
- 基因别名
- FGFB
- UniProt
- P09038
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
FGF2, also known as basic fibroblast growth factor, is a key regulator of cellular function in various tissues. It binds and activates FGF receptors, primarily through the RAS-MAPK pathway, to regulate processes like cell proliferation, migration, differentiation, and angiogenesis. FGF2 has been implicated in a number of diseases and pathological conditions. It plays an important role in wound healing and tissue engineering, but its overexpression can also lead to cellular overgrowth and malignancy. FGF2 has been linked to bone disorders like osteoporosis, osteomalacia, and pathological bone fractures by impacting genetic expression and signaling pathways. It has also been associated with neurological conditions such as Parkinson's disease, Alzheimer's disease, and schizophrenia, where altered FGF2 levels can have both positive and negative effects. Additionally, FGF2 has been shown to function as an immunomodulatory factor, regulating inflammatory processes in diseases like asthma and COPD. Overall, the diverse functions of FGF2 make it an important target for understanding and potentially treating a wide range of diseases.