人 FGF16 抗体对
01AB02663
Fibroblast growth factor 16 (FGF16) is a secreted, heparin-binding growth factor that plays a significant role in embryonic development, cell proliferation, and tissue repair. It features a conserved beta-trefoil core domain that mediates binding to fibroblast growth factor receptors and heparan sulfate. Unlike many secreted proteins, FGF16 utilizes an internal hydrophobic motif for unconventional endoplasmic reticulum targeting and secretion. It signals primarily through FGFR1 and FGFR2 to regulate cardiac development and homeostasis. Clinically, pathogenic loss-of-function variants in the FGF16 gene are the cause of X-linked metacarpal 4-5 fusion, a congenital limb malformation. Emerging research also suggests its involvement in cardiac injury responses and metabolic regulation.
| 规格 | 起售价 |
|---|---|
| 登录后可查看 | |
技术参数
- 靶点基因名
- FGF16
- 蛋白别名
- fibroblast growth factor 16; FGF16
- UniProt
- O43320
- 物种
- Human
产品详情
- 靶点名称
- FGF16
- 蛋白名称
- fibroblast growth factor 16
- 蛋白别名
- Fibroblast growth factor 16; FGF-16
- 靶点基因名
- FGF16
- UniProt
- O43320
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Fibroblast growth factor 16 (FGF16) is a secreted, heparin-binding growth factor that plays a significant role in embryonic development, cell proliferation, and tissue repair. It features a conserved beta-trefoil core domain that mediates binding to fibroblast growth factor receptors and heparan sulfate. Unlike many secreted proteins, FGF16 utilizes an internal hydrophobic motif for unconventional endoplasmic reticulum targeting and secretion. It signals primarily through FGFR1 and FGFR2 to regulate cardiac development and homeostasis. Clinically, pathogenic loss-of-function variants in the FGF16 gene are the cause of X-linked metacarpal 4-5 fusion, a congenital limb malformation. Emerging research also suggests its involvement in cardiac injury responses and metabolic regulation.