人 FGF12 抗体对
01AB03111
Fibroblast growth factor 12 (FGF12), also known as FGF homologous factor 1B, is an intracellular, non-secreted member of the FGF homologous factors subfamily that lacks a classical signal peptide and heparin-binding capacity, distinguishing it from canonical paracrine FGFs. FGF12 is predominantly expressed in the nervous system, where it binds and modulates voltage-gated sodium channels (Nav1.x), positively regulating their activity and thereby influencing neuronal excitability and action potential firing. It localizes mainly to the cytoplasm and nucleus and does not activate classical FGF receptors, instead acting as an intracellular modulator of ion channel function. Disease relevance centers on cardiac arrhythmia and neuro-excitability phenotypes: FGF12 variants or altered expression have been associated with inherited arrhythmia syndromes and abnormal cardiac conduction, as well as potential roles in epilepsy and other channelopathy-related disorders, consistent with its critical regulatory role in excitable tissues.
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技术参数
- 靶点基因名
- FGF12
- 基因别名
- FGF12B; FHF1
- 蛋白别名
- fibroblast growth factor 12; FGF12
- UniProt
- P61328
- 物种
- Human
产品详情
- 靶点名称
- FGF12
- 蛋白名称
- fibroblast growth factor 12
- 蛋白别名
- Fibroblast growth factor 12; FGF-12; Fibroblast growth factor homologous factor 1; FHF-1; Myocyte-activating factor
- 靶点基因名
- FGF12
- 基因别名
- FGF12B; FHF1
- UniProt
- P61328
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Fibroblast growth factor 12 (FGF12), also known as FGF homologous factor 1B, is an intracellular, non-secreted member of the FGF homologous factors subfamily that lacks a classical signal peptide and heparin-binding capacity, distinguishing it from canonical paracrine FGFs. FGF12 is predominantly expressed in the nervous system, where it binds and modulates voltage-gated sodium channels (Nav1.x), positively regulating their activity and thereby influencing neuronal excitability and action potential firing. It localizes mainly to the cytoplasm and nucleus and does not activate classical FGF receptors, instead acting as an intracellular modulator of ion channel function. Disease relevance centers on cardiac arrhythmia and neuro-excitability phenotypes: FGF12 variants or altered expression have been associated with inherited arrhythmia syndromes and abnormal cardiac conduction, as well as potential roles in epilepsy and other channelopathy-related disorders, consistent with its critical regulatory role in excitable tissues.