人 FGF1 抗体对
01AB03469
Fibroblast growth factor 1 (FGF1), also called acidic FGF, is a heparin-binding growth factor encoded by the FGF1 gene and produced as a 155–amino acid polypeptide that yields a nonglycosylated protein of about 17–18 kDa. It acts mainly as a potent mitogen and survival factor, regulating cell proliferation, differentiation, migration, and angiogenesis through binding to fibroblast growth factor receptors (especially FGFR1) in a heparan-sulfate–dependent manner and activating downstream MAPK/ERK and PI3K–AKT signaling cascades. FGF1 is expressed in many tissues, can signal both extracellularly and within the nucleus, and participates in processes such as embryonic development, tissue repair, and bone formation. Pathologically, dysregulated FGF1 signaling contributes to tumor growth and invasion, while in metabolism it modulates adipose and hepatic glucose handling and has shown the ability to normalize blood glucose in diabetic mouse models.
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技术参数
- 靶点基因名
- FGF1
- 基因别名
- FGFA
- 蛋白别名
- fibroblast growth factor 1; FGF1
- UniProt
- P05230
- 物种
- Human
产品详情
- 靶点名称
- FGF1
- 蛋白名称
- fibroblast growth factor 1
- 蛋白别名
- Fibroblast growth factor 1; FGF-1; Acidic fibroblast growth factor; aFGF; Endothelial cell growth factor; ECGF; Heparin-binding growth factor 1; HBGF-1
- 靶点基因名
- FGF1
- 基因别名
- FGFA
- UniProt
- P05230
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Fibroblast growth factor 1 (FGF1), also called acidic FGF, is a heparin-binding growth factor encoded by the FGF1 gene and produced as a 155–amino acid polypeptide that yields a nonglycosylated protein of about 17–18 kDa. It acts mainly as a potent mitogen and survival factor, regulating cell proliferation, differentiation, migration, and angiogenesis through binding to fibroblast growth factor receptors (especially FGFR1) in a heparan-sulfate–dependent manner and activating downstream MAPK/ERK and PI3K–AKT signaling cascades. FGF1 is expressed in many tissues, can signal both extracellularly and within the nucleus, and participates in processes such as embryonic development, tissue repair, and bone formation. Pathologically, dysregulated FGF1 signaling contributes to tumor growth and invasion, while in metabolism it modulates adipose and hepatic glucose handling and has shown the ability to normalize blood glucose in diabetic mouse models.