人 FER 抗体对
01AB03057
FER tyrosine kinase (FER) is a cytosolic non-receptor tyrosine kinase of the FPS/FES family. Acting downstream of growth factor receptors such as EGFR and KIT, it regulates cytoskeletal dynamics, cell adhesion, and migration by phosphorylating substrates like cortactin and p120-catenin. FER is integral to the maintenance of cell-cell junctions and leukocyte recruitment. Functioning as a proto-oncogene, its dysregulation contributes to cancer progression and metastasis. Additionally, FER plays a role in regulating vascular permeability and is implicated in neuroinflammatory processes and neuronal ceroid lipofuscinosis.
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技术参数
- 靶点基因名
- FER
- 基因别名
- TYK3
- 蛋白别名
- FER tyrosine kinase; FER
- UniProt
- P16591
- 物种
- Human
产品详情
- 靶点名称
- FER
- 蛋白名称
- FER tyrosine kinase
- 蛋白别名
- Tyrosine-protein kinase Fer; Feline encephalitis virus-related kinase FER; Fujinami poultry sarcoma/Feline sarcoma-related protein Fer; Proto-oncogene c-Fer; Tyrosine kinase 3; p94-Fer
- 靶点基因名
- FER
- 基因别名
- TYK3
- UniProt
- P16591
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
FER tyrosine kinase (FER) is a cytosolic non-receptor tyrosine kinase of the FPS/FES family. Acting downstream of growth factor receptors such as EGFR and KIT, it regulates cytoskeletal dynamics, cell adhesion, and migration by phosphorylating substrates like cortactin and p120-catenin. FER is integral to the maintenance of cell-cell junctions and leukocyte recruitment. Functioning as a proto-oncogene, its dysregulation contributes to cancer progression and metastasis. Additionally, FER plays a role in regulating vascular permeability and is implicated in neuroinflammatory processes and neuronal ceroid lipofuscinosis.