人 FCRLB 抗体对
01AB00237
Fc receptor like B (FCRLB), encoded by the FCRLB gene, is a member of the Fc receptor-like (FCRL) family, which shares homology with classical Fc receptors but lacks high-affinity binding to immunoglobulins. This type I transmembrane protein contains extracellular immunoglobulin (Ig)-like domains and a cytoplasmic tail with immunoreceptor tyrosine-based inhibition motifs (ITIMs), suggesting regulatory roles in B-cell signaling. FCRLB is predominantly expressed in secondary lymphoid tissues, particularly in germinal center B cells, and may modulate B-cell receptor (BCL) signaling or immune tolerance. FCRLB is implicated in autoimmune disorders and B-cell malignancies. Genome-wide studies link FCRLB polymorphisms to autoimmune conditions like rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Additionally, aberrant FCRLB expression is observed in chronic lymphocytic leukemia (CLL).
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技术参数
- 靶点基因名
- FCRLB
- 基因别名
- FCRL2; FCRLM2; FCRY; FREB2
- 蛋白别名
- Fc receptor like B; FCRLB
- UniProt
- Q6BAA4
- 物种
- Human
产品详情
- 靶点名称
- FCRLB
- 蛋白名称
- Fc receptor like B
- 蛋白别名
- Fc receptor-like B; Fc receptor homolog expressed in B-cells protein 2; FREB-2; Fc receptor-like and mucin-like protein 2; Fc receptor-like protein 2; Fc receptor-related protein Y; FcRY
- 靶点基因名
- FCRLB
- 基因别名
- FCRL2; FCRLM2; FCRY; FREB2
- UniProt
- Q6BAA4
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Fc receptor like B (FCRLB), encoded by the FCRLB gene, is a member of the Fc receptor-like (FCRL) family, which shares homology with classical Fc receptors but lacks high-affinity binding to immunoglobulins. This type I transmembrane protein contains extracellular immunoglobulin (Ig)-like domains and a cytoplasmic tail with immunoreceptor tyrosine-based inhibition motifs (ITIMs), suggesting regulatory roles in B-cell signaling. FCRLB is predominantly expressed in secondary lymphoid tissues, particularly in germinal center B cells, and may modulate B-cell receptor (BCL) signaling or immune tolerance. FCRLB is implicated in autoimmune disorders and B-cell malignancies. Genome-wide studies link FCRLB polymorphisms to autoimmune conditions like rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Additionally, aberrant FCRLB expression is observed in chronic lymphocytic leukemia (CLL).