人 FCRL6 抗体对
01AB02658
Fc receptor like 6 (FCRL6) is a type I transmembrane immunoregulatory glycoprotein predominantly expressed on mature cytotoxic CD8+ T cells and NK cells. Unlike classical Fc receptors, FCRL6 functions as a receptor for MHC class II molecules, specifically binding HLA-DR. Its cytoplasmic tail contains tyrosine-based motifs, including an ITIM-like sequence that recruits SHP-2 phosphatase to mediate inhibitory signaling in cytotoxic lymphocytes. FCRL6 expression increases with lymphocyte differentiation and cytolytic potential, suggesting a role in modulating immune responses. In the context of oncology, FCRL6 is upregulated on lymphocytes infiltrating HLA class II-expressing tumors, where it contributes to immune tolerance and tumor evasion. It is also associated with combined immunodeficiency and thrombocytopenia in genetic studies.
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技术参数
- 靶点基因名
- FCRL6
- 基因别名
- FCRH6
- 蛋白别名
- Fc receptor like 6; FCRL6
- UniProt
- Q6DN72
- 物种
- Human
产品详情
- 靶点名称
- FCRL6
- 蛋白名称
- Fc receptor like 6
- 蛋白别名
- Fc receptor-like protein 6; FcR-like protein 6; FcRL6; Fc receptor homolog 6; FcRH6; IFGP6
- 靶点基因名
- FCRL6
- 基因别名
- FCRH6
- UniProt
- Q6DN72
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Fc receptor like 6 (FCRL6) is a type I transmembrane immunoregulatory glycoprotein predominantly expressed on mature cytotoxic CD8+ T cells and NK cells. Unlike classical Fc receptors, FCRL6 functions as a receptor for MHC class II molecules, specifically binding HLA-DR. Its cytoplasmic tail contains tyrosine-based motifs, including an ITIM-like sequence that recruits SHP-2 phosphatase to mediate inhibitory signaling in cytotoxic lymphocytes. FCRL6 expression increases with lymphocyte differentiation and cytolytic potential, suggesting a role in modulating immune responses. In the context of oncology, FCRL6 is upregulated on lymphocytes infiltrating HLA class II-expressing tumors, where it contributes to immune tolerance and tumor evasion. It is also associated with combined immunodeficiency and thrombocytopenia in genetic studies.