人 FCGR2B 抗体对
01AB00812
Fc gamma receptor IIb (FCGR2B), also known as CD32B, is a low-affinity inhibitory receptor for the Fc region of immunoglobulin gamma (IgG) and is a member of the immunoglobulin superfamily. Structurally, FCGR2B features two immunoglobulin-like domains arranged at a 70° angle, forming a heart-shaped molecule, with critical IgG-binding residues located in specific loop regions of the second domain. It exists in two main isoforms, FCGR2B1 and FCGR2B2, generated by alternative splicing, and contains an immunoreceptor tyrosine-based inhibitory motif (ITIM) in its cytoplasmic tail. FCGR2B is primarily expressed on B cells, monocytes, and some myeloid cells, where it regulates immune responses by inhibiting activating FcγRs, modulating B cell activation, and promoting the phagocytosis of immune complexes. Functionally, its ITIM motif recruits phosphatases such as SHIP1 and SHIP2, dampening cell activation pathways. Genetic variations in FCGR2B are associated with increased susceptibility to autoimmune diseases, notably systemic lupus erythematosus (SLE).
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技术参数
- 靶点基因名
- FCGR2B
- 基因别名
- CD32; FCG2; IGFR2
- 蛋白别名
- Fc gamma receptor IIb; FCGR2B
- UniProt
- P31994
- 物种
- Human
产品详情
- 靶点名称
- FCGR2B
- 蛋白名称
- Fc gamma receptor IIb
- 蛋白别名
- Low affinity immunoglobulin gamma Fc region receptor II-b; IgG Fc receptor II-b; CDw32; Fc-gamma RII-b; Fc-gamma-RIIb; FcRII-b; CD antigen CD32
- 靶点基因名
- FCGR2B
- 基因别名
- CD32; FCG2; IGFR2
- UniProt
- P31994
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Fc gamma receptor IIb (FCGR2B), also known as CD32B, is a low-affinity inhibitory receptor for the Fc region of immunoglobulin gamma (IgG) and is a member of the immunoglobulin superfamily. Structurally, FCGR2B features two immunoglobulin-like domains arranged at a 70° angle, forming a heart-shaped molecule, with critical IgG-binding residues located in specific loop regions of the second domain. It exists in two main isoforms, FCGR2B1 and FCGR2B2, generated by alternative splicing, and contains an immunoreceptor tyrosine-based inhibitory motif (ITIM) in its cytoplasmic tail. FCGR2B is primarily expressed on B cells, monocytes, and some myeloid cells, where it regulates immune responses by inhibiting activating FcγRs, modulating B cell activation, and promoting the phagocytosis of immune complexes. Functionally, its ITIM motif recruits phosphatases such as SHIP1 and SHIP2, dampening cell activation pathways. Genetic variations in FCGR2B are associated with increased susceptibility to autoimmune diseases, notably systemic lupus erythematosus (SLE).