人 FAS 抗体对
01AB04020
Tumor necrosis factor receptor superfamily member 6 (FAS), also known as CD95, is a type I transmembrane protein that plays a crucial role in regulating apoptosis, or programmed cell death. It is primarily expressed on the surface of various immune cells and is activated upon binding to its ligand, Fas ligand (FasL), which leads to the formation of a death-inducing signaling complex (DISC). This process activates caspases, triggering a cascade of events that culminate in apoptosis. Dysregulation of FAS has been implicated in several diseases, particularly autoimmune disorders, where excessive apoptosis can lead to tissue damage, and cancers, such as lymphomas, where tumor cells may downregulate FAS to evade immune-mediated cell death.
| 规格 | 起售价 |
|---|---|
| 登录后可查看 | |
技术参数
- 靶点基因名
- FAS
- 基因别名
- APT1; FAS1; TNFRSF6
- 蛋白别名
- Fas cell surface death receptor; FAS
- UniProt
- P25445
- 物种
- Human
产品详情
- 靶点名称
- FAS
- 蛋白名称
- Fas cell surface death receptor
- 蛋白别名
- Tumor necrosis factor receptor superfamily member 6; Apo-1 antigen; Apoptosis-mediating surface antigen FAS; FASLG receptor; CD antigen CD95
- 靶点基因名
- FAS
- 基因别名
- APT1; FAS1; TNFRSF6
- UniProt
- P25445
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Tumor necrosis factor receptor superfamily member 6 (FAS), also known as CD95, is a type I transmembrane protein that plays a crucial role in regulating apoptosis, or programmed cell death. It is primarily expressed on the surface of various immune cells and is activated upon binding to its ligand, Fas ligand (FasL), which leads to the formation of a death-inducing signaling complex (DISC). This process activates caspases, triggering a cascade of events that culminate in apoptosis. Dysregulation of FAS has been implicated in several diseases, particularly autoimmune disorders, where excessive apoptosis can lead to tissue damage, and cancers, such as lymphomas, where tumor cells may downregulate FAS to evade immune-mediated cell death.