抗人 FAM81A 抗体对
01AB02413
Family with sequence similarity 81 member A (FAM81A) is a brain-enriched postsynaptic scaffold protein localized to the postsynaptic density (PSD) of excitatory glutamatergic synapses. It plays a central role in organizing the PSD by facilitating the assembly of key components, including PSD-95, SynGAP, and NMDA receptors. FAM81A promotes liquid-liquid phase separation, which leads to the formation of membrane-less condensates that enlarge dendritic spines and support neuronal firing. The protein contains an SMC_N-like domain, suggesting potential interactions with nuclear or chromatin-associated proteins, possibly involved in synapse-to-nucleus signaling. While FAM81A is essential for normal neuronal activity and synaptic organization, its specific clinical associations remain under investigation.
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技术参数
- 靶点基因名
- FAM81A
- 蛋白别名
- family with sequence similarity 81 member A; FAM81A
- UniProt
- Q8TBF8
- 物种
- Human
产品详情
- 靶点名称
- FAM81A
- 蛋白名称
- family with sequence similarity 81 member A
- 蛋白别名
- Protein FAM81A
- 靶点基因名
- FAM81A
- UniProt
- Q8TBF8
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Family with sequence similarity 81 member A (FAM81A) is a brain-enriched postsynaptic scaffold protein localized to the postsynaptic density (PSD) of excitatory glutamatergic synapses. It plays a central role in organizing the PSD by facilitating the assembly of key components, including PSD-95, SynGAP, and NMDA receptors. FAM81A promotes liquid-liquid phase separation, which leads to the formation of membrane-less condensates that enlarge dendritic spines and support neuronal firing. The protein contains an SMC_N-like domain, suggesting potential interactions with nuclear or chromatin-associated proteins, possibly involved in synapse-to-nucleus signaling. While FAM81A is essential for normal neuronal activity and synaptic organization, its specific clinical associations remain under investigation.