人 FAM3C 抗体对
01AB03729
FAM3 metabolism regulating signaling molecule C (FAM3C), also known as interleukin-like EMT inducer (ILEI), is a secreted protein characterized by a GG domain and is part of the FAM3 family, encoded by the FAM3C gene on human chromosome 7. Structurally, FAM3C exists as both monomers and covalent dimers, displaying a unique β-β-α fold rather than the classical four-helix-bundle typical of interleukins, indicating it is not evolutionarily related to interleukins. Functionally, FAM3C is implicated in promoting epithelial-to-mesenchymal transition (EMT), a process vital for development and wound healing but also associated with cancer metastasis. Its upregulation and mislocalization have been observed in several cancers, including breast and colon, correlating with poor prognosis and enhanced tumor formation and metastasis. Beyond oncology, reduced FAM3C levels are linked to the onset of sporadic Alzheimer’s disease.
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技术参数
- 靶点基因名
- FAM3C
- 基因别名
- ILEI
- 蛋白别名
- FAM3 metabolism regulating signaling molecule C; FAM3C
- UniProt
- Q92520
- 物种
- Human
产品详情
- 靶点名称
- FAM3C
- 蛋白名称
- FAM3 metabolism regulating signaling molecule C
- 蛋白别名
- Protein FAM3C; Interleukin-like EMT inducer
- 靶点基因名
- FAM3C
- 基因别名
- ILEI
- UniProt
- Q92520
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
FAM3 metabolism regulating signaling molecule C (FAM3C), also known as interleukin-like EMT inducer (ILEI), is a secreted protein characterized by a GG domain and is part of the FAM3 family, encoded by the FAM3C gene on human chromosome 7. Structurally, FAM3C exists as both monomers and covalent dimers, displaying a unique β-β-α fold rather than the classical four-helix-bundle typical of interleukins, indicating it is not evolutionarily related to interleukins. Functionally, FAM3C is implicated in promoting epithelial-to-mesenchymal transition (EMT), a process vital for development and wound healing but also associated with cancer metastasis. Its upregulation and mislocalization have been observed in several cancers, including breast and colon, correlating with poor prognosis and enhanced tumor formation and metastasis. Beyond oncology, reduced FAM3C levels are linked to the onset of sporadic Alzheimer’s disease.