人 FAM3B 抗体对
01AB00234
FAM3B, also known as PANDER (pancreatic-derived factor), is a member of the FAM3 cytokine-like gene family. It encodes a 235-amino acid protein that is highly expressed and secreted from pancreatic alpha and beta cells. PANDER plays a role in regulating glucose homeostasis, insulin sensitivity, and hepatic lipogenesis. Overexpression of PANDER promotes apoptosis of beta cells, inhibits insulin secretion, and induces insulin resistance in the liver, leading to increased gluconeogenesis. Conversely, PANDER deficiency protects against hyperglycemia and insulin resistance in diet-induced and genetic mouse models of obesity and diabetes. PANDER knockout mice exhibit enhanced glucose tolerance and reduced hepatic steatosis, suggesting a potential role for PANDER in the pathogenesis of type 2 diabetes.
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技术参数
- 靶点基因名
- FAM3B
- 基因别名
- C21orf11; C21orf76
- 蛋白别名
- FAM3 metabolism regulating signaling molecule B; FAM3B
- UniProt
- P58499
- 物种
- Human
产品详情
- 靶点名称
- FAM3B
- 蛋白名称
- FAM3 metabolism regulating signaling molecule B
- 蛋白别名
- Protein FAM3B; Cytokine-like protein 2-21; Pancreatic-derived factor; PANDER
- 靶点基因名
- FAM3B
- 基因别名
- C21orf11; C21orf76
- UniProt
- P58499
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
FAM3B, also known as PANDER (pancreatic-derived factor), is a member of the FAM3 cytokine-like gene family. It encodes a 235-amino acid protein that is highly expressed and secreted from pancreatic alpha and beta cells. PANDER plays a role in regulating glucose homeostasis, insulin sensitivity, and hepatic lipogenesis. Overexpression of PANDER promotes apoptosis of beta cells, inhibits insulin secretion, and induces insulin resistance in the liver, leading to increased gluconeogenesis. Conversely, PANDER deficiency protects against hyperglycemia and insulin resistance in diet-induced and genetic mouse models of obesity and diabetes. PANDER knockout mice exhibit enhanced glucose tolerance and reduced hepatic steatosis, suggesting a potential role for PANDER in the pathogenesis of type 2 diabetes.