人 FAF1 抗体对
01AB01693
Fas-associated factor 1 (FAF1) is a 74-kDa multifunctional scaffolding protein involved in apoptosis and cellular regulation. It binds directly to the Fas receptor and components of the Fas-death-inducing signaling complex (Fas-DISC) such as FADD and caspase-8, facilitating Fas-mediated apoptosis by acting upstream of caspase-8. FAF1 contains multiple ubiquitin-related domains (UBA, UBL1, UBL2, UBX) which enable interactions with ubiquitinated proteins and the valosin-containing protein complex, implicating it in ubiquitin-mediated proteasomal degradation and endoplasmic reticulum-associated protein degradation (ERAD). FAF1 also negatively regulates the NF-κB signaling pathway by inhibiting IKK activation and preventing nuclear translocation of NF-κB. Dysregulation of FAF1 is linked to diseases including cancer, where decreased FAF1 expression may contribute to tumor progression, and neurodegenerative disorders through its role in cell survival and death. FAF1 additionally influences antiviral immune responses by regulating type I interferon production during RNA virus infections, highlighting its diverse roles in cell death and immune signaling.
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技术参数
- 靶点基因名
- FAF1
- 基因别名
- UBXD12; UBXN3A
- 蛋白别名
- Fas associated factor 1; FAF1
- UniProt
- Q9UNN5
- 物种
- Human
产品详情
- 靶点名称
- FAF1
- 蛋白名称
- Fas associated factor 1
- 蛋白别名
- FAS-associated factor 1; hFAF1; UBX domain-containing protein 12; UBX domain-containing protein 3A
- 靶点基因名
- FAF1
- 基因别名
- UBXD12; UBXN3A
- UniProt
- Q9UNN5
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Fas-associated factor 1 (FAF1) is a 74-kDa multifunctional scaffolding protein involved in apoptosis and cellular regulation. It binds directly to the Fas receptor and components of the Fas-death-inducing signaling complex (Fas-DISC) such as FADD and caspase-8, facilitating Fas-mediated apoptosis by acting upstream of caspase-8. FAF1 contains multiple ubiquitin-related domains (UBA, UBL1, UBL2, UBX) which enable interactions with ubiquitinated proteins and the valosin-containing protein complex, implicating it in ubiquitin-mediated proteasomal degradation and endoplasmic reticulum-associated protein degradation (ERAD). FAF1 also negatively regulates the NF-κB signaling pathway by inhibiting IKK activation and preventing nuclear translocation of NF-κB. Dysregulation of FAF1 is linked to diseases including cancer, where decreased FAF1 expression may contribute to tumor progression, and neurodegenerative disorders through its role in cell survival and death. FAF1 additionally influences antiviral immune responses by regulating type I interferon production during RNA virus infections, highlighting its diverse roles in cell death and immune signaling.