抗人 EXO1 抗体对
01AB03865
Exonuclease 1 (EXO1) is a crucial enzyme involved in DNA metabolism, specifically in DNA repair and replication. It exhibits 5' to 3' exonuclease activity, allowing it to degrade single-stranded and double-stranded DNA, and possesses RNase activity, which enables it to cleave RNA on DNA/RNA hybrids. EXO1 plays a significant role in the DNA mismatch repair (MMR) pathway and homologous recombination, where it is essential for processing DNA double-strand breaks (DSBs) during meiosis and mitosis. Dysregulation of EXO1 has been associated with several diseases, particularly cancer. For instance, mutations or altered expression of EXO1 can lead to genomic instability, contributing to tumorigenesis in various cancers, including colorectal and breast cancers. Additionally, studies have shown that EXO1 is involved in the cellular response to DNA damage; its overactivity can lead to excessive degradation of DNA at replication forks, potentially resulting in cell death or senescence.
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技术参数
- 靶点基因名
- EXO1
- 基因别名
- EXOI; HEX1
- 蛋白别名
- exonuclease 1; EXO1
- UniProt
- Q9UQ84
- 物种
- Human
产品详情
- 靶点名称
- EXO1
- 蛋白名称
- exonuclease 1
- 蛋白别名
- Exonuclease 1; hExo1; Exonuclease I; hExoI
- 靶点基因名
- EXO1
- 基因别名
- EXOI; HEX1
- UniProt
- Q9UQ84
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Exonuclease 1 (EXO1) is a crucial enzyme involved in DNA metabolism, specifically in DNA repair and replication. It exhibits 5' to 3' exonuclease activity, allowing it to degrade single-stranded and double-stranded DNA, and possesses RNase activity, which enables it to cleave RNA on DNA/RNA hybrids. EXO1 plays a significant role in the DNA mismatch repair (MMR) pathway and homologous recombination, where it is essential for processing DNA double-strand breaks (DSBs) during meiosis and mitosis. Dysregulation of EXO1 has been associated with several diseases, particularly cancer. For instance, mutations or altered expression of EXO1 can lead to genomic instability, contributing to tumorigenesis in various cancers, including colorectal and breast cancers. Additionally, studies have shown that EXO1 is involved in the cellular response to DNA damage; its overactivity can lead to excessive degradation of DNA at replication forks, potentially resulting in cell death or senescence.