人 EPHB4 抗体对
01AB01476
EPH receptor B4 (EPHB4), is a member of the receptor tyrosine kinase family that plays a pivotal role in cell communication and developmental processes. EPHB4 binds promiscuously to transmembrane ephrin-B ligands on adjacent cells, initiating contact-dependent bidirectional signaling: forward signaling through the receptor and reverse signaling through the ligand. This interaction is essential for regulating cell adhesion, migration, and tissue boundary formation. EPHB4, especially in concert with its major ligand ephrin-B2 (EFNB2), is critical in heart morphogenesis, angiogenesis, and the remodeling and permeability of blood vessels. Variations or dysregulation in EPHB4 signaling have been implicated in several diseases, notably cancer, where EPHB4 influences tumor growth, metastasis, and pathological angiogenesis. In addition, recent studies link EPHB4 to vascular anomalies such as central conducting lymphatic anomaly and brain arteriovenous malformations.
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技术参数
- 靶点基因名
- EPHB4
- 基因别名
- HTK; MYK1; TYRO11
- 蛋白别名
- EPH receptor B4; EPHB4
- UniProt
- P54760
- 物种
- Human
产品详情
- 靶点名称
- EPHB4
- 蛋白名称
- EPH receptor B4
- 蛋白别名
- Ephrin type-B receptor 4; Hepatoma transmembrane kinase; Tyrosine-protein kinase TYRO11
- 靶点基因名
- EPHB4
- 基因别名
- HTK; MYK1; TYRO11
- UniProt
- P54760
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
EPH receptor B4 (EPHB4), is a member of the receptor tyrosine kinase family that plays a pivotal role in cell communication and developmental processes. EPHB4 binds promiscuously to transmembrane ephrin-B ligands on adjacent cells, initiating contact-dependent bidirectional signaling: forward signaling through the receptor and reverse signaling through the ligand. This interaction is essential for regulating cell adhesion, migration, and tissue boundary formation. EPHB4, especially in concert with its major ligand ephrin-B2 (EFNB2), is critical in heart morphogenesis, angiogenesis, and the remodeling and permeability of blood vessels. Variations or dysregulation in EPHB4 signaling have been implicated in several diseases, notably cancer, where EPHB4 influences tumor growth, metastasis, and pathological angiogenesis. In addition, recent studies link EPHB4 to vascular anomalies such as central conducting lymphatic anomaly and brain arteriovenous malformations.