人 EPHA2 抗体对
01AB01130
EPH receptor A2 (EPHA2) is a 130 kDa transmembrane glycoprotein belonging to the ephrin receptor subfamily of tyrosine kinases. It contains an extracellular ligand-binding domain, a single transmembrane segment, and an intracellular kinase domain. EPHA2 binds ephrin-A ligands and mediates cell-cell signaling to regulate various developmental processes, particularly in the nervous system. It plays key roles in cell adhesion, migration, proliferation, and differentiation. EPHA2 is involved in angiogenesis, mammary gland development, and bone remodeling. In pathological conditions, EPHA2 is frequently overexpressed in various cancers, including breast, prostate, and lung cancers, where it promotes tumor growth and metastasis. Additionally, mutations in EPHA2 are associated with age-related cortical cataracts and congenital cataracts. EPHA2 also serves as an entry receptor for certain viruses, including hepatitis C virus and human cytomegalovirus.
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技术参数
- 靶点基因名
- EPHA2
- 基因别名
- ECK
- 蛋白别名
- EPH receptor A2; EPHA2
- UniProt
- P29317
- 物种
- Human
产品详情
- 靶点名称
- EPHA2
- 蛋白名称
- EPH receptor A2
- 蛋白别名
- Ephrin type-A receptor 2; Epithelial cell kinase; Tyrosine-protein kinase receptor ECK
- 靶点基因名
- EPHA2
- 基因别名
- ECK
- UniProt
- P29317
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
EPH receptor A2 (EPHA2) is a 130 kDa transmembrane glycoprotein belonging to the ephrin receptor subfamily of tyrosine kinases. It contains an extracellular ligand-binding domain, a single transmembrane segment, and an intracellular kinase domain. EPHA2 binds ephrin-A ligands and mediates cell-cell signaling to regulate various developmental processes, particularly in the nervous system. It plays key roles in cell adhesion, migration, proliferation, and differentiation. EPHA2 is involved in angiogenesis, mammary gland development, and bone remodeling. In pathological conditions, EPHA2 is frequently overexpressed in various cancers, including breast, prostate, and lung cancers, where it promotes tumor growth and metastasis. Additionally, mutations in EPHA2 are associated with age-related cortical cataracts and congenital cataracts. EPHA2 also serves as an entry receptor for certain viruses, including hepatitis C virus and human cytomegalovirus.