人 EpCAM 抗体对
01AB03183
Epithelial cell adhesion molecule (EpCAM) is a type I transmembrane glycoprotein expressed on the surface of most simple and stratified epithelia. It mediates calcium-independent homophilic cell-cell adhesion and contributes to the structural organization of tight junctions. Beyond its adhesive properties, EpCAM functions as an active signaling receptor through regulated intramembrane proteolysis, which releases its intracellular domain to co-activate the transcription of genes involved in cell proliferation and differentiation. Clinically, EpCAM is widely overexpressed in epithelial carcinomas, where it serves as a diagnostic marker and a target for immunotherapy. Germline deletions in the EPCAM gene are a known cause of Lynch syndrome, while biallelic loss-of-function mutations result in congenital tufting enteropathy, a severe intestinal disorder.
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技术参数
- 靶点基因名
- EPCAM
- 基因别名
- GA733-2; M1S2; M4S1; MIC18; TACSTD1; TROP1
- 蛋白别名
- epithelial cell adhesion molecule; EpCAM
- UniProt
- P16422
- 物种
- Human
产品详情
- 靶点名称
- EpCAM
- 蛋白名称
- epithelial cell adhesion molecule
- 蛋白别名
- Epithelial cell adhesion molecule; Ep-CAM; Adenocarcinoma-associated antigen; Cell surface glycoprotein Trop-1; Epithelial cell surface antigen; Epithelial glycoprotein; EGP; Epithelial glycoprotein 314; EGP314; hEGP314; KS 1/4 antigen; KSA; Major gastrointestinal tumor-associated protein GA733-2; Tumor-associated calcium signal transducer 1; CD antigen CD326
- 靶点基因名
- EPCAM
- 基因别名
- GA733-2; M1S2; M4S1; MIC18; TACSTD1; TROP1
- UniProt
- P16422
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Epithelial cell adhesion molecule (EpCAM) is a type I transmembrane glycoprotein expressed on the surface of most simple and stratified epithelia. It mediates calcium-independent homophilic cell-cell adhesion and contributes to the structural organization of tight junctions. Beyond its adhesive properties, EpCAM functions as an active signaling receptor through regulated intramembrane proteolysis, which releases its intracellular domain to co-activate the transcription of genes involved in cell proliferation and differentiation. Clinically, EpCAM is widely overexpressed in epithelial carcinomas, where it serves as a diagnostic marker and a target for immunotherapy. Germline deletions in the EPCAM gene are a known cause of Lynch syndrome, while biallelic loss-of-function mutations result in congenital tufting enteropathy, a severe intestinal disorder.