人 EPC1 抗体对
01AB02455
Enhancer of polycomb 1 (EPC1) is a conserved chromatin regulatory protein that serves as a fundamental scaffold within histone acetyltransferase (HAT) complexes. It is a key subunit of the NuA4 HAT complex, where it bridges the catalytic acetyltransferase enzyme with other regulatory subunits to stimulate the acetylation of histone H4 and H2A. This modification is essential for gene activation and the maintenance of open chromatin states. Additionally, EPC1 contributes to epigenetic silencing by integrating with non-canonical Polycomb repressive complex 1 (PRC1) variants, facilitating the deposition of H2AK119ub1. Through these dual roles in transcriptional activation and repression, EPC1 helps maintain the delicate balance of histone modifications across the genome.
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技术参数
- 靶点基因名
- EPC1
- 蛋白别名
- enhancer of polycomb 1; EPC1
- UniProt
- Q9H2F5
- 物种
- Human
产品详情
- 靶点名称
- EPC1
- 蛋白名称
- enhancer of polycomb 1
- 蛋白别名
- Enhancer of polycomb homolog 1;enhancer of polycomb homolog 1
- 靶点基因名
- EPC1
- UniProt
- Q9H2F5
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Enhancer of polycomb 1 (EPC1) is a conserved chromatin regulatory protein that serves as a fundamental scaffold within histone acetyltransferase (HAT) complexes. It is a key subunit of the NuA4 HAT complex, where it bridges the catalytic acetyltransferase enzyme with other regulatory subunits to stimulate the acetylation of histone H4 and H2A. This modification is essential for gene activation and the maintenance of open chromatin states. Additionally, EPC1 contributes to epigenetic silencing by integrating with non-canonical Polycomb repressive complex 1 (PRC1) variants, facilitating the deposition of H2AK119ub1. Through these dual roles in transcriptional activation and repression, EPC1 helps maintain the delicate balance of histone modifications across the genome.