人 EP300 抗体对
01AB01128
E1A binding protein p300 (EP300) is a multifunctional histone acetyltransferase that plays a pivotal role in gene regulation by acetylating histones, thereby relaxing chromatin structure and facilitating transcriptional activation. As a transcriptional coactivator, p300 interacts with numerous transcription factors-including CREB, p53, and HIF1A-using specialized domains such as the bromodomain and KIX domain, and is involved in diverse cellular processes like cell growth, differentiation, and development. Beyond histones, p300 acetylates non-histone proteins, modulating their activity and stability, and is essential for normal development before and after birth. Disease associations primarily include its role as a tumor suppressor, with EP300 mutations linked to increased genome instability, altered antitumor immunity, and responsiveness to immunotherapy in various cancers. Additionally, loss-of-function mutations in EP300 cause Rubinstein-Taybi syndrome, a developmental disorder characterized by intellectual disability and distinctive physical features.
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技术参数
- 靶点基因名
- EP300
- 基因别名
- P300
- 蛋白别名
- EP300 lysine acetyltransferase; EP300
- UniProt
- Q09472
- 物种
- Human
产品详情
- 靶点名称
- EP300
- 蛋白名称
- EP300 lysine acetyltransferase
- 蛋白别名
- Histone acetyltransferase p300; p300 HAT; E1A-associated protein p300; Histone butyryltransferase p300; Histone crotonyltransferase p300; Protein 2-hydroxyisobutyryltransferase p300; Protein lactyltransferas p300; Protein propionyltransferase p300);E1A binding protein p300
- 靶点基因名
- EP300
- 基因别名
- P300
- UniProt
- Q09472
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
E1A binding protein p300 (EP300) is a multifunctional histone acetyltransferase that plays a pivotal role in gene regulation by acetylating histones, thereby relaxing chromatin structure and facilitating transcriptional activation. As a transcriptional coactivator, p300 interacts with numerous transcription factors-including CREB, p53, and HIF1A-using specialized domains such as the bromodomain and KIX domain, and is involved in diverse cellular processes like cell growth, differentiation, and development. Beyond histones, p300 acetylates non-histone proteins, modulating their activity and stability, and is essential for normal development before and after birth. Disease associations primarily include its role as a tumor suppressor, with EP300 mutations linked to increased genome instability, altered antitumor immunity, and responsiveness to immunotherapy in various cancers. Additionally, loss-of-function mutations in EP300 cause Rubinstein-Taybi syndrome, a developmental disorder characterized by intellectual disability and distinctive physical features.