人 ENTPD3 抗体对
01AB00803
Ectonucleoside triphosphate diphosphohydrolase 3 (ENTPD3), also known as CD39L3 or NTPDase-3, is an integral membrane protein encoded by the ENTPD3 gene. It belongs to the E-NTPDase family and hydrolyzes extracellular nucleotides, particularly ATP, ADP, UTP, and UDP, with a threefold preference for ATP and UTP over ADP. ENTPD3 contains four apyrase-conserved regions and is activated by divalent metal ions like Ca²⁺ and Mg²⁺, playing a critical role in purinergic signaling by regulating extracellular nucleotide levels. It is highly expressed in brain, pancreas, spleen, and prostate tissues, where it modulates physiological processes such as insulin secretion in pancreatic β-cells. Structurally, ENTPD3 consists of two major domains with a conserved secondary structure topology, forming a substrate-binding pocket. Dysregulation of ENTPD3 has been implicated in diseases, including cancer, where its activity influences tumor immune evasion and therapeutic responses.
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技术参数
- 靶点基因名
- ENTPD3
- 基因别名
- CD39L3
- 蛋白别名
- ectonucleoside triphosphate diphosphohydrolase 3; ENTPD3
- UniProt
- O75355
- 物种
- Human
产品详情
- 靶点名称
- ENTPD3
- 蛋白名称
- ectonucleoside triphosphate diphosphohydrolase 3
- 蛋白别名
- Ectonucleoside triphosphate diphosphohydrolase 3; NTPDase 3; CD39 antigen-like 3; Ecto-ATP diphosphohydrolase 3; Ecto-ATPDase 3; Ecto-ATPase 3; Ecto-apyrase 3; HB6
- 靶点基因名
- ENTPD3
- 基因别名
- CD39L3
- UniProt
- O75355
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Ectonucleoside triphosphate diphosphohydrolase 3 (ENTPD3), also known as CD39L3 or NTPDase-3, is an integral membrane protein encoded by the ENTPD3 gene. It belongs to the E-NTPDase family and hydrolyzes extracellular nucleotides, particularly ATP, ADP, UTP, and UDP, with a threefold preference for ATP and UTP over ADP. ENTPD3 contains four apyrase-conserved regions and is activated by divalent metal ions like Ca²⁺ and Mg²⁺, playing a critical role in purinergic signaling by regulating extracellular nucleotide levels. It is highly expressed in brain, pancreas, spleen, and prostate tissues, where it modulates physiological processes such as insulin secretion in pancreatic β-cells. Structurally, ENTPD3 consists of two major domains with a conserved secondary structure topology, forming a substrate-binding pocket. Dysregulation of ENTPD3 has been implicated in diseases, including cancer, where its activity influences tumor immune evasion and therapeutic responses.