人 ENTPD2 抗体对
01AB01125
Ectonucleoside triphosphate diphosphohydrolase 2 (ENTPD2), also known as NTPDase2, is an integral membrane protein and a member of the E-NTPDase family, primarily responsible for hydrolyzing extracellular nucleoside triphosphates and diphosphates, such as ATP and ADP, to regulate purinergic signaling in various tissues. ENTPD2 is widely expressed in multiple organs, including the brain, liver, kidney, and immune tissues, and plays a key role in modulating neurotransmission, inflammation, and vascular function. The protein is subject to alternative splicing, resulting in multiple transcript variants, and its expression can be influenced by extracellular ATP and anti-inflammatory cytokines like IL-10, particularly in astrocytes during neuroinflammatory conditions. Clinically, ENTPD2 has been identified as a prognostic marker in several cancers, including kidney renal clear cell carcinoma, liver hepatocellular carcinoma, and lung adenocarcinoma, and is associated with diseases such as severe COVID-19 and frontal sinus disorders.
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技术参数
- 靶点基因名
- ENTPD2
- 基因别名
- CD39L1
- 蛋白别名
- ectonucleoside triphosphate diphosphohydrolase 2; ENTPD2
- UniProt
- Q9Y5L3
- 物种
- Human
产品详情
- 靶点名称
- ENTPD2
- 蛋白名称
- ectonucleoside triphosphate diphosphohydrolase 2
- 蛋白别名
- Ectonucleoside triphosphate diphosphohydrolase 2; NTPDase 2; CD39 antigen-like 1; Ecto-ATP diphosphohydrolase 2; Ecto-ATPDase 2; Ecto-ATPase 2
- 靶点基因名
- ENTPD2
- 基因别名
- CD39L1
- UniProt
- Q9Y5L3
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Ectonucleoside triphosphate diphosphohydrolase 2 (ENTPD2), also known as NTPDase2, is an integral membrane protein and a member of the E-NTPDase family, primarily responsible for hydrolyzing extracellular nucleoside triphosphates and diphosphates, such as ATP and ADP, to regulate purinergic signaling in various tissues. ENTPD2 is widely expressed in multiple organs, including the brain, liver, kidney, and immune tissues, and plays a key role in modulating neurotransmission, inflammation, and vascular function. The protein is subject to alternative splicing, resulting in multiple transcript variants, and its expression can be influenced by extracellular ATP and anti-inflammatory cytokines like IL-10, particularly in astrocytes during neuroinflammatory conditions. Clinically, ENTPD2 has been identified as a prognostic marker in several cancers, including kidney renal clear cell carcinoma, liver hepatocellular carcinoma, and lung adenocarcinoma, and is associated with diseases such as severe COVID-19 and frontal sinus disorders.