人 ENPP7 抗体对
01AB04014
Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7), also known as alkaline sphingomyelinase, is a crucial enzyme encoded by the ENPP7 gene in humans. This enzyme primarily functions in the digestion of sphingomyelin, converting it into ceramide and phosphocholine, with optimal activity at a pH of 9.0, predominantly in the small intestine. ENPP7 plays a significant role in lipid metabolism and may influence cholesterol absorption by forming complexes with cholesterol in intestinal membranes. Its deficiency has been linked to various diseases, particularly colorectal cancer, where reduced enzyme activity correlates with tumorigenesis. Studies indicate that ENPP7's hydrolysis of sphingomyelin produces ceramide, which can inhibit cell proliferation and promote apoptosis, suggesting its protective role against cancer.
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技术参数
- 靶点基因名
- ENPP7
- 蛋白别名
- ectonucleotide pyrophosphatase/phosphodiesterase 7; ENPP7
- UniProt
- Q6UWV6
- 物种
- Human
产品详情
- 靶点名称
- ENPP7
- 蛋白名称
- ectonucleotide pyrophosphatase/phosphodiesterase 7
- 蛋白别名
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 7; E-NPP 7; NPP-7; Alkaline sphingomyelin phosphodiesterase; Intestinal alkaline sphingomyelinase; Alk-SMase
- 靶点基因名
- ENPP7
- UniProt
- Q6UWV6
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7), also known as alkaline sphingomyelinase, is a crucial enzyme encoded by the ENPP7 gene in humans. This enzyme primarily functions in the digestion of sphingomyelin, converting it into ceramide and phosphocholine, with optimal activity at a pH of 9.0, predominantly in the small intestine. ENPP7 plays a significant role in lipid metabolism and may influence cholesterol absorption by forming complexes with cholesterol in intestinal membranes. Its deficiency has been linked to various diseases, particularly colorectal cancer, where reduced enzyme activity correlates with tumorigenesis. Studies indicate that ENPP7's hydrolysis of sphingomyelin produces ceramide, which can inhibit cell proliferation and promote apoptosis, suggesting its protective role against cancer.