抗人 EN2 抗体对
01AB03862
Homeobox protein engrailed-2 (EN2) is a transcription factor that plays a crucial role in the development of the central nervous system, particularly the cerebellum. EN2 contains a highly conserved homeodomain that allows it to bind to DNA and regulate gene expression during embryonic development. It is essential for proper patterning, foliation, and growth of the cerebellum. Altered expression of EN2 can lead to abnormal cerebellar morphology and foliation. Interestingly, EN2 can also be secreted by cells and taken up by neighboring cells, where it may influence their behavior. Dysregulation of EN2 has been associated with several diseases, including autism spectrum disorder (ASD), where genetic variations in the EN2 gene have been identified as susceptibility factors. Additionally, EN2 is expressed in various cancers, such as prostate, bladder, and breast cancer.
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技术参数
- 靶点基因名
- EN2
- 蛋白别名
- engrailed homeobox 2; EN2
- UniProt
- P19622
- 物种
- Human
产品详情
- 靶点名称
- EN2
- 蛋白名称
- engrailed homeobox 2
- 蛋白别名
- Homeobox protein engrailed-2; Homeobox protein en-2; Hu-En-2
- 靶点基因名
- EN2
- UniProt
- P19622
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Homeobox protein engrailed-2 (EN2) is a transcription factor that plays a crucial role in the development of the central nervous system, particularly the cerebellum. EN2 contains a highly conserved homeodomain that allows it to bind to DNA and regulate gene expression during embryonic development. It is essential for proper patterning, foliation, and growth of the cerebellum. Altered expression of EN2 can lead to abnormal cerebellar morphology and foliation. Interestingly, EN2 can also be secreted by cells and taken up by neighboring cells, where it may influence their behavior. Dysregulation of EN2 has been associated with several diseases, including autism spectrum disorder (ASD), where genetic variations in the EN2 gene have been identified as susceptibility factors. Additionally, EN2 is expressed in various cancers, such as prostate, bladder, and breast cancer.