人 EIF4G3 抗体对
01AB01122
Eukaryotic translation initiation factor 4 gamma 3 (EIF4G3) is a key component of the eIF4F protein complex, which plays a central role in the initiation of eukaryotic translation by recognizing the mRNA cap structure and facilitating the recruitment of ribosomes to mRNA, as well as unwinding secondary structures at the 5' end of mRNAs to promote efficient translation initiation. EIF4G3 acts as a scaffold protein, organizing other initiation factors and mRNA, and is notably enriched in the nucleus of spermatocytes, particularly within the XY body, suggesting a specialized role in regulating mRNA metabolism and translation during meiosis and spermatogenesis. Mutations in EIF4G3 have been shown in mouse models to cause male infertility due to meiotic arrest, likely by impairing the translation of key proteins such as HSPA2, which is essential for progression through meiosis. Additionally, aberrant expression of circ-EIF4G3 has been implicated in promoting proliferation, invasion, and migration in gastric cancer, highlighting its relevance in disease contexts.
| 规格 | 起售价 |
|---|---|
| 登录后可查看 | |
技术参数
- 靶点基因名
- EIF4G3
- 蛋白别名
- eukaryotic translation initiation factor 4 gamma 3; EIF4G3
- UniProt
- O43432
- 物种
- Human
产品详情
- 靶点名称
- EIF4G3
- 蛋白名称
- eukaryotic translation initiation factor 4 gamma 3
- 蛋白别名
- Eukaryotic translation initiation factor 4 gamma 3; eIF-4-gamma 3; eIF-4G 3; eIF4G 3; eIF-4-gamma II; eIF4GII
- 靶点基因名
- EIF4G3
- UniProt
- O43432
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Eukaryotic translation initiation factor 4 gamma 3 (EIF4G3) is a key component of the eIF4F protein complex, which plays a central role in the initiation of eukaryotic translation by recognizing the mRNA cap structure and facilitating the recruitment of ribosomes to mRNA, as well as unwinding secondary structures at the 5' end of mRNAs to promote efficient translation initiation. EIF4G3 acts as a scaffold protein, organizing other initiation factors and mRNA, and is notably enriched in the nucleus of spermatocytes, particularly within the XY body, suggesting a specialized role in regulating mRNA metabolism and translation during meiosis and spermatogenesis. Mutations in EIF4G3 have been shown in mouse models to cause male infertility due to meiotic arrest, likely by impairing the translation of key proteins such as HSPA2, which is essential for progression through meiosis. Additionally, aberrant expression of circ-EIF4G3 has been implicated in promoting proliferation, invasion, and migration in gastric cancer, highlighting its relevance in disease contexts.