人 EIF4EBP1 抗体对
01AB04183
Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1), also known as 4E-BP1, is a key regulator of protein synthesis that inhibits cap-dependent translation by binding to the translation initiation factor eIF4E. This interaction prevents the formation of the eIF4F complex, essential for mRNA translation initiation. EIF4EBP1 is phosphorylated in response to various signals, particularly those from the mechanistic target of rapamycin (mTOR) pathway, leading to its dissociation from eIF4E and subsequent activation of translation. Dysregulation of EIF4EBP1 has been linked to several diseases, particularly cancers; high levels of phosphorylated 4E-BP1 are often associated with poor outcomes in malignancies such as glioblastoma and breast cancer. Additionally, its expression is influenced by oncogenic signaling pathways, which can promote tumorigenesis.
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技术参数
- 靶点基因名
- EIF4EBP1
- 蛋白别名
- eukaryotic translation initiation factor 4E binding protein 1; EIF4EBP1
- UniProt
- Q13541
- 物种
- Human
产品详情
- 靶点名称
- EIF4EBP1
- 蛋白名称
- eukaryotic translation initiation factor 4E binding protein 1
- 蛋白别名
- Eukaryotic translation initiation factor 4E-binding protein 1; 4E-BP1; eIF4E-binding protein 1; Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-I
- 靶点基因名
- EIF4EBP1
- UniProt
- Q13541
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1), also known as 4E-BP1, is a key regulator of protein synthesis that inhibits cap-dependent translation by binding to the translation initiation factor eIF4E. This interaction prevents the formation of the eIF4F complex, essential for mRNA translation initiation. EIF4EBP1 is phosphorylated in response to various signals, particularly those from the mechanistic target of rapamycin (mTOR) pathway, leading to its dissociation from eIF4E and subsequent activation of translation. Dysregulation of EIF4EBP1 has been linked to several diseases, particularly cancers; high levels of phosphorylated 4E-BP1 are often associated with poor outcomes in malignancies such as glioblastoma and breast cancer. Additionally, its expression is influenced by oncogenic signaling pathways, which can promote tumorigenesis.