人 EIF4E 抗体对
01AB00230
Eukaryotic translation initiation factor 4E (eIF4E) is a crucial protein that binds to the 5' cap of mRNA, facilitating the initiation of translation. This factor is a component of the eIF4F complex, which includes eIF4G and eIF4A, and plays a pivotal role in recruiting ribosomes to mRNA for protein synthesis. eIF4E's activity is tightly regulated by various mechanisms, including phosphorylation and interactions with 4E-binding proteins (4E-BPs), which can inhibit its function. Dysregulation of eIF4E is linked to several diseases, particularly cancer, where its overexpression correlates with increased cell growth and metastasis. Additionally, eIF4E has been implicated in neurodevelopmental disorders such as autism spectrum disorder and Fragile X syndrome. Its multifaceted roles in mRNA processing, export, and translation underscore its significance in cellular physiology and pathology .
| 规格 | 起售价 |
|---|---|
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技术参数
- 靶点基因名
- EIF4E
- 基因别名
- EIF4EL1; EIF4F
- 蛋白别名
- eukaryotic translation initiation factor 4E; EIF4E
- UniProt
- P06730
- 物种
- Human
产品详情
- 靶点名称
- EIF4E
- 蛋白名称
- eukaryotic translation initiation factor 4E
- 蛋白别名
- Eukaryotic translation initiation factor 4E; eIF-4E; eIF4E; eIF-4F 25 kDa subunit; mRNA cap-binding protein
- 靶点基因名
- EIF4E
- 基因别名
- EIF4EL1; EIF4F
- UniProt
- P06730
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Eukaryotic translation initiation factor 4E (eIF4E) is a crucial protein that binds to the 5' cap of mRNA, facilitating the initiation of translation. This factor is a component of the eIF4F complex, which includes eIF4G and eIF4A, and plays a pivotal role in recruiting ribosomes to mRNA for protein synthesis. eIF4E's activity is tightly regulated by various mechanisms, including phosphorylation and interactions with 4E-binding proteins (4E-BPs), which can inhibit its function. Dysregulation of eIF4E is linked to several diseases, particularly cancer, where its overexpression correlates with increased cell growth and metastasis. Additionally, eIF4E has been implicated in neurodevelopmental disorders such as autism spectrum disorder and Fragile X syndrome. Its multifaceted roles in mRNA processing, export, and translation underscore its significance in cellular physiology and pathology .