人 EIF4B 抗体偶对
01AB00224
Eukaryotic translation initiation factor 4B (eIF4B) is a protein that plays a central role in promoting translation initiation by helping to unwind secondary structures within mRNA's 5' untranslated regions (UTRs). It functions by stimulating the helicase activity of eIF4A and interacting with eIF3 and the 18S ribosomal RNA. eIF4B is essential for translating mRNAs with complex secondary structures, many of which encode proteins involved in vital cellular processes. Its activity is regulated through phosphorylation events, particularly by the mTOR/PI3K and MAPK pathways, and it is subject to post-transcriptional modification. Overexpression of eIF4B has been linked to cancer progression due to its influence on the translation of pro-survival mRNAs.
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技术参数
- 靶点基因名
- EIF4B
- 蛋白别名
- eukaryotic translation initiation factor 4B; EIF4B
- UniProt
- P23588
- 物种
- Human
产品详情
- 靶点名称
- EIF4B
- 蛋白名称
- eukaryotic translation initiation factor 4B
- 蛋白别名
- Eukaryotic translation initiation factor 4B; eIF-4B
- 靶点基因名
- EIF4B
- UniProt
- P23588
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Eukaryotic translation initiation factor 4B (eIF4B) is a protein that plays a central role in promoting translation initiation by helping to unwind secondary structures within mRNA's 5' untranslated regions (UTRs). It functions by stimulating the helicase activity of eIF4A and interacting with eIF3 and the 18S ribosomal RNA. eIF4B is essential for translating mRNAs with complex secondary structures, many of which encode proteins involved in vital cellular processes. Its activity is regulated through phosphorylation events, particularly by the mTOR/PI3K and MAPK pathways, and it is subject to post-transcriptional modification. Overexpression of eIF4B has been linked to cancer progression due to its influence on the translation of pro-survival mRNAs.