人 EHD3 抗体对
01AB01685
EH domain containing 3 (EHD3) is a membrane-associated protein of the EHD family that regulates endocytic recycling and membrane tubulation. It facilitates the transport of cargo from early endosomes to the endocytic recycling compartment and the plasma membrane. Structurally, EHD3 contains an N-terminal dynamin-like G domain, a central coiled-coil for oligomerization, and a C-terminal EH domain that binds calcium. In cardiac myocytes, EHD3 is essential for the proper targeting of ion transporters; it directly interacts with ankyrin-B to control the surface expression of the Na+/Ca2+ exchanger (NCX1). Clinically, EHD3 deficiency is linked to cardiac conduction disorders and arrhythmogenesis. The loss of EHD3 leads to impaired NCX1 membrane localization and altered electrical excitability, predisposing the heart to arrhythmias.
| 规格 | 起售价 |
|---|---|
| 登录后可查看 | |
技术参数
- 靶点基因名
- EHD3
- 基因别名
- EHD2; PAST3
- 蛋白别名
- EH domain containing 3; EHD3
- UniProt
- Q9NZN3
- 物种
- Human
产品详情
- 靶点名称
- EHD3
- 蛋白名称
- EH domain containing 3
- 蛋白别名
- EH domain-containing protein 3; PAST homolog 3
- 靶点基因名
- EHD3
- 基因别名
- EHD2; PAST3
- UniProt
- Q9NZN3
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
EH domain containing 3 (EHD3) is a membrane-associated protein of the EHD family that regulates endocytic recycling and membrane tubulation. It facilitates the transport of cargo from early endosomes to the endocytic recycling compartment and the plasma membrane. Structurally, EHD3 contains an N-terminal dynamin-like G domain, a central coiled-coil for oligomerization, and a C-terminal EH domain that binds calcium. In cardiac myocytes, EHD3 is essential for the proper targeting of ion transporters; it directly interacts with ankyrin-B to control the surface expression of the Na+/Ca2+ exchanger (NCX1). Clinically, EHD3 deficiency is linked to cardiac conduction disorders and arrhythmogenesis. The loss of EHD3 leads to impaired NCX1 membrane localization and altered electrical excitability, predisposing the heart to arrhythmias.