人 EG-VEGF 抗体对
01AB00563
Prokineticin 1 (PROK1), also known as Endocrine Gland-Vascular Endothelial Growth Factor (EG-VEGF), is a small peptide hormone primarily expressed in steroidogenic endocrine organs such as the ovary, testis, adrenal glands, and placenta. It features a conserved N-terminal hexapeptide sequence (AVITGA) and ten cysteine residues forming five disulfide bridges, essential for its bioactivity. PROK1 induces proliferation, migration, and fenestration of capillary endothelial cells in endocrine tissues, playing a key role in angiogenesis under hypoxic conditions. It binds to G-protein-coupled receptors PROKR1 and PROKR2 with high affinity, mediating diverse physiological functions including gastrointestinal motility, reproduction, and vascular development. Dysregulation of PROK1 signaling has been implicated in diseases such as cancer and ischemia.
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技术参数
- 靶点基因名
- PROK1
- 蛋白别名
- prokineticin 1; EG-VEGF
- UniProt
- P58294
- 物种
- Human
产品详情
- 靶点名称
- EG-VEGF
- 蛋白名称
- prokineticin 1
- 蛋白别名
- Prokineticin-1; Endocrine-gland-derived vascular endothelial growth factor; EG-VEGF; Mambakine
- 靶点基因名
- PROK1
- UniProt
- P58294
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Prokineticin 1 (PROK1), also known as Endocrine Gland-Vascular Endothelial Growth Factor (EG-VEGF), is a small peptide hormone primarily expressed in steroidogenic endocrine organs such as the ovary, testis, adrenal glands, and placenta. It features a conserved N-terminal hexapeptide sequence (AVITGA) and ten cysteine residues forming five disulfide bridges, essential for its bioactivity. PROK1 induces proliferation, migration, and fenestration of capillary endothelial cells in endocrine tissues, playing a key role in angiogenesis under hypoxic conditions. It binds to G-protein-coupled receptors PROKR1 and PROKR2 with high affinity, mediating diverse physiological functions including gastrointestinal motility, reproduction, and vascular development. Dysregulation of PROK1 signaling has been implicated in diseases such as cancer and ischemia.