人 EFEMP1 抗体对
01AB04010
Epidermal growth factor-containing fibulin-like extracellular matrix protein 1 (EFEMP1) is a glycoprotein that belongs to the fibulin family, characterized by multiple epidermal growth factor (EGF)-like repeats and a fibulin-type domain. This protein is primarily involved in the structural organization of the extracellular matrix, influencing cell adhesion, migration, and tissue integrity. EFEMP1 is expressed in various tissues, including the retina, where it plays a crucial role in maintaining retinal structure and function. The protein's EGF-like domains are thought to interact with cell surface receptors, modulating signaling pathways that are essential for cellular processes such as proliferation and differentiation. EFEMP1 is notably involved in the development of retinal structures, and mutations in the EFEMP1 gene are linked to Doyne honeycomb retinal dystrophy. Additionally, EFEMP1 has been implicated in various cancers, including endometrial carcinoma and gliomas, where it acts as a tumor suppressor; its downregulation is associated with increased tumor aggressiveness and poor prognosis.
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技术参数
- 靶点基因名
- EFEMP1
- 基因别名
- FBLN3; FBNL
- 蛋白别名
- EGF containing fibulin extracellular matrix protein 1; EFEMP1
- UniProt
- Q12805
- 物种
- Human
产品详情
- 靶点名称
- EFEMP1
- 蛋白名称
- EGF containing fibulin extracellular matrix protein 1
- 蛋白别名
- EGF-containing fibulin-like extracellular matrix protein 1; Extracellular protein S1-5; Fibrillin-like protein; Fibulin-3; FIBL-3
- 靶点基因名
- EFEMP1
- 基因别名
- FBLN3; FBNL
- UniProt
- Q12805
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Epidermal growth factor-containing fibulin-like extracellular matrix protein 1 (EFEMP1) is a glycoprotein that belongs to the fibulin family, characterized by multiple epidermal growth factor (EGF)-like repeats and a fibulin-type domain. This protein is primarily involved in the structural organization of the extracellular matrix, influencing cell adhesion, migration, and tissue integrity. EFEMP1 is expressed in various tissues, including the retina, where it plays a crucial role in maintaining retinal structure and function. The protein's EGF-like domains are thought to interact with cell surface receptors, modulating signaling pathways that are essential for cellular processes such as proliferation and differentiation. EFEMP1 is notably involved in the development of retinal structures, and mutations in the EFEMP1 gene are linked to Doyne honeycomb retinal dystrophy. Additionally, EFEMP1 has been implicated in various cancers, including endometrial carcinoma and gliomas, where it acts as a tumor suppressor; its downregulation is associated with increased tumor aggressiveness and poor prognosis.