人 EDIL3 抗体对
01AB01119
EGF like repeats and discoidin domains 3 (EDIL3), also known as DEL-1, is a glycoprotein comprising three epidermal growth factor (EGF)-like repeats and two discoidin I-like domains. It contains an Arg-Gly-Asp (RGD) motif that facilitates binding to integrins, particularly αvβ3 and α5β1, influencing cell adhesion, migration, and angiogenesis. EDIL3 plays a pivotal role in embryonic development, vascular morphogenesis, and osteoblast differentiation by activating the ERK/Runx2 pathway. It also modulates inflammation and immune responses by preventing leukocyte adhesion to endothelial cells. In pathological contexts, EDIL3 is implicated in cancer progression, including hepatocellular carcinoma, gastric cancer, and colon cancer, where its overexpression promotes tumor angiogenesis, proliferation, and immune infiltration. It has also been linked to keloid formation and dilated cardiomyopathy.
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技术参数
- 靶点基因名
- EDIL3
- 基因别名
- DEL1
- 蛋白别名
- EGF like repeats and discoidin domains 3; EDIL3
- UniProt
- O43854
- 物种
- Human
产品详情
- 靶点名称
- EDIL3
- 蛋白名称
- EGF like repeats and discoidin domains 3
- 蛋白别名
- EGF-like repeat and discoidin I-like domain-containing protein 3; Developmentally-regulated endothelial cell locus 1 protein; Integrin-binding protein DEL1
- 靶点基因名
- EDIL3
- 基因别名
- DEL1
- UniProt
- O43854
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
EGF like repeats and discoidin domains 3 (EDIL3), also known as DEL-1, is a glycoprotein comprising three epidermal growth factor (EGF)-like repeats and two discoidin I-like domains. It contains an Arg-Gly-Asp (RGD) motif that facilitates binding to integrins, particularly αvβ3 and α5β1, influencing cell adhesion, migration, and angiogenesis. EDIL3 plays a pivotal role in embryonic development, vascular morphogenesis, and osteoblast differentiation by activating the ERK/Runx2 pathway. It also modulates inflammation and immune responses by preventing leukocyte adhesion to endothelial cells. In pathological contexts, EDIL3 is implicated in cancer progression, including hepatocellular carcinoma, gastric cancer, and colon cancer, where its overexpression promotes tumor angiogenesis, proliferation, and immune infiltration. It has also been linked to keloid formation and dilated cardiomyopathy.