人 EDF1 抗体对
01AB03253
Endothelial differentiation related factor 1 (EDF1) is a highly conserved transcriptional coactivator that plays a dual role in both the nucleus and the cytoplasm. In the nucleus, it acts as a bridge between the TATA-binding protein and various gene-specific transcription factors, enhancing the activity of nuclear receptors such as NR5A1, LXRA, and PPARG, as well as ATF1/2 and CREB1. In the cytoplasm of endothelial cells, EDF1 functions as a calmodulin-binding protein. By sequestering calmodulin, it negatively regulates nitric oxide synthase activity and modulates nitric oxide signaling pathways. Functionally, EDF1 is involved in regulating endothelial differentiation, lipid metabolism, and hormone-induced cardiomyocyte hypertrophy.
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技术参数
- 靶点基因名
- EDF1
- 蛋白别名
- endothelial differentiation related factor 1; EDF1
- UniProt
- O60869
- 物种
- Human
产品详情
- 靶点名称
- EDF1
- 蛋白名称
- endothelial differentiation related factor 1
- 蛋白别名
- Endothelial differentiation-related factor 1; EDF-1; Multiprotein-bridging factor 1; MBF1
- 靶点基因名
- EDF1
- UniProt
- O60869
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Endothelial differentiation related factor 1 (EDF1) is a highly conserved transcriptional coactivator that plays a dual role in both the nucleus and the cytoplasm. In the nucleus, it acts as a bridge between the TATA-binding protein and various gene-specific transcription factors, enhancing the activity of nuclear receptors such as NR5A1, LXRA, and PPARG, as well as ATF1/2 and CREB1. In the cytoplasm of endothelial cells, EDF1 functions as a calmodulin-binding protein. By sequestering calmodulin, it negatively regulates nitric oxide synthase activity and modulates nitric oxide signaling pathways. Functionally, EDF1 is involved in regulating endothelial differentiation, lipid metabolism, and hormone-induced cardiomyocyte hypertrophy.