人 EDA2R 抗体对
01AB03063
Tumor necrosis factor receptor superfamily member 27 (EDA2R), also known as X-linked ectodysplasin-A2 receptor, is a type III transmembrane protein that plays a critical role in ectodermal development. It specifically binds to the EDA-A2 isoform of ectodysplasin, which is essential for the formation and maintenance of various ectodermal structures, including hair follicles, teeth, and sweat glands. EDA2R activates intracellular signaling pathways, notably the NF-κB and JNK pathways, through interactions with adaptor proteins such as TRAF3 and TRAF6. Dysregulation or mutations in the EDA2R gene are associated with X-linked hypohidrotic ectodermal dysplasia, a condition characterized by sparse hair, missing teeth, and reduced sweating due to impaired ectodermal development. Additionally, EDA2R has been implicated in tumorigenesis, as its signaling pathways can influence cell proliferation and apoptosis in various cancers.
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技术参数
- 靶点基因名
- EDA2R
- 基因别名
- TNFRSF27; XEDAR
- 蛋白别名
- ectodysplasin A2 receptor; EDA2R
- UniProt
- Q9HAV5
- 物种
- Human
产品详情
- 靶点名称
- EDA2R
- 蛋白名称
- ectodysplasin A2 receptor
- 蛋白别名
- Tumor necrosis factor receptor superfamily member 27; X-linked ectodysplasin-A2 receptor; EDA-A2 receptor
- 靶点基因名
- EDA2R
- 基因别名
- TNFRSF27; XEDAR
- UniProt
- Q9HAV5
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Tumor necrosis factor receptor superfamily member 27 (EDA2R), also known as X-linked ectodysplasin-A2 receptor, is a type III transmembrane protein that plays a critical role in ectodermal development. It specifically binds to the EDA-A2 isoform of ectodysplasin, which is essential for the formation and maintenance of various ectodermal structures, including hair follicles, teeth, and sweat glands. EDA2R activates intracellular signaling pathways, notably the NF-κB and JNK pathways, through interactions with adaptor proteins such as TRAF3 and TRAF6. Dysregulation or mutations in the EDA2R gene are associated with X-linked hypohidrotic ectodermal dysplasia, a condition characterized by sparse hair, missing teeth, and reduced sweating due to impaired ectodermal development. Additionally, EDA2R has been implicated in tumorigenesis, as its signaling pathways can influence cell proliferation and apoptosis in various cancers.