人 ECPAS 抗体对
01AB01117
Ecm29 proteasome adaptor and scaffold (ECPAS) is an adaptor and scaffold protein that binds to the 26S proteasome, motor proteins, and various compartment-specific proteins, facilitating the coupling of the proteasome to different cellular compartments and structures. It plays a crucial role in regulating proteasome localization and mobilization, particularly in neurons and immune cells, by linking the proteasome to microtubules, vesicles, and centrosomes, thereby orchestrating key cellular processes such as actin cytoskeleton remodeling, lysosome trafficking, and antigen extraction during immune synapse formation. Ecm29 also mediates the disassembly of the 26S proteasome in response to physiological stresses like glucose starvation, adapting global proteolysis to cellular needs and countering proteotoxic stress. Dysfunction or altered regulation of Ecm29 can disrupt proteasome distribution and activity, potentially contributing to diseases involving impaired protein homeostasis, such as neurodegenerative disorders and immune dysfunctions.
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技术参数
- 靶点基因名
- ECPAS
- 基因别名
- ECM29; KIAA0368
- 蛋白别名
- Ecm29 proteasome adaptor and scaffold; ECPAS
- UniProt
- Q5VYK3
- 物种
- Human
产品详情
- 靶点名称
- ECPAS
- 蛋白名称
- Ecm29 proteasome adaptor and scaffold
- 蛋白别名
- Proteasome adapter and scaffold protein ECM29; Ecm29 proteasome adapter and scaffold; Proteasome-associated protein ECM29 homolog
- 靶点基因名
- ECPAS
- 基因别名
- ECM29; KIAA0368
- UniProt
- Q5VYK3
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Ecm29 proteasome adaptor and scaffold (ECPAS) is an adaptor and scaffold protein that binds to the 26S proteasome, motor proteins, and various compartment-specific proteins, facilitating the coupling of the proteasome to different cellular compartments and structures. It plays a crucial role in regulating proteasome localization and mobilization, particularly in neurons and immune cells, by linking the proteasome to microtubules, vesicles, and centrosomes, thereby orchestrating key cellular processes such as actin cytoskeleton remodeling, lysosome trafficking, and antigen extraction during immune synapse formation. Ecm29 also mediates the disassembly of the 26S proteasome in response to physiological stresses like glucose starvation, adapting global proteolysis to cellular needs and countering proteotoxic stress. Dysfunction or altered regulation of Ecm29 can disrupt proteasome distribution and activity, potentially contributing to diseases involving impaired protein homeostasis, such as neurodegenerative disorders and immune dysfunctions.