人 DTX1 抗体对
01AB02171
Deltex E3 ubiquitin ligase 1 (DTX1) is an E3 ubiquitin ligase that mediates the ubiquitination and subsequent proteasomal degradation of specific target proteins, including MEKK1. It is a well-characterized regulator of the Notch signaling pathway, where it typically acts as a positive modulator of Notch activity. Through its ligase activity, DTX1 influences various cellular signaling cascades and proteostatic mechanisms. Clinically, alterations in DTX1 expression are associated with several malignancies. It is linked to poor survival outcomes in diffuse large B-cell lymphoma and regulates c-FLIP levels in gastric cancer. Furthermore, reduced expression of DTX1 in head and neck squamous cell carcinoma suggests a potential role as a tumor suppressor in certain oncogenic contexts.
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技术参数
- 靶点基因名
- DTX1
- 蛋白别名
- deltex E3 ubiquitin ligase 1; DTX1
- UniProt
- Q86Y01
- 物种
- Human
产品详情
- 靶点名称
- DTX1
- 蛋白名称
- deltex E3 ubiquitin ligase 1
- 蛋白别名
- E3 ubiquitin-protein ligase DTX1; Protein deltex-1; Deltex1; hDTX1; RING-type E3 ubiquitin transferase DTX1
- 靶点基因名
- DTX1
- UniProt
- Q86Y01
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Deltex E3 ubiquitin ligase 1 (DTX1) is an E3 ubiquitin ligase that mediates the ubiquitination and subsequent proteasomal degradation of specific target proteins, including MEKK1. It is a well-characterized regulator of the Notch signaling pathway, where it typically acts as a positive modulator of Notch activity. Through its ligase activity, DTX1 influences various cellular signaling cascades and proteostatic mechanisms. Clinically, alterations in DTX1 expression are associated with several malignancies. It is linked to poor survival outcomes in diffuse large B-cell lymphoma and regulates c-FLIP levels in gastric cancer. Furthermore, reduced expression of DTX1 in head and neck squamous cell carcinoma suggests a potential role as a tumor suppressor in certain oncogenic contexts.