人 DSG4 抗体对
01AB02166
Desmoglein 4 (DSG4) is a calcium-dependent cadherin and a core transmembrane component of desmosomes, essential for cell-cell adhesion in epithelial tissues. It is highly expressed in hair follicle keratinocytes and the upper layers of the epidermis, where it coordinates the transition from cellular proliferation to differentiation. DSG4-mediated desmosomes provide mechanical strength and regulate signaling pathways necessary for hair shaft formation and epidermal barrier integrity. Clinically, mutations in DSG4 are the primary cause of localized autosomal recessive hypotrichosis (Hypotrichosis 6), characterized by fragile, sparse hair due to underdeveloped hair follicles. DSG4 variants are also associated with monilethrix-like congenital hypotrichosis, a disorder of the hair cortex resulting in beaded hair shafts and significant hair dysplasia.
| 规格 | 起售价 |
|---|---|
| 登录后可查看 | |
技术参数
- 靶点基因名
- DSG4
- 基因别名
- CDHF13
- 蛋白别名
- desmoglein 4; DSG4
- UniProt
- Q86SJ6
- 物种
- Human
产品详情
- 靶点名称
- DSG4
- 蛋白名称
- desmoglein 4
- 蛋白别名
- Desmoglein-4; Cadherin family member 13
- 靶点基因名
- DSG4
- 基因别名
- CDHF13
- UniProt
- Q86SJ6
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Desmoglein 4 (DSG4) is a calcium-dependent cadherin and a core transmembrane component of desmosomes, essential for cell-cell adhesion in epithelial tissues. It is highly expressed in hair follicle keratinocytes and the upper layers of the epidermis, where it coordinates the transition from cellular proliferation to differentiation. DSG4-mediated desmosomes provide mechanical strength and regulate signaling pathways necessary for hair shaft formation and epidermal barrier integrity. Clinically, mutations in DSG4 are the primary cause of localized autosomal recessive hypotrichosis (Hypotrichosis 6), characterized by fragile, sparse hair due to underdeveloped hair follicles. DSG4 variants are also associated with monilethrix-like congenital hypotrichosis, a disorder of the hair cortex resulting in beaded hair shafts and significant hair dysplasia.